@Article{or.2022.028075,
AUTHOR = {ZHIXUN XIAO, QIUYUN XU, HAIQING WANG, XIAOTONG ZHOU, YANTING ZHU, CHENGBEI BAO, LIHONG CHEN, PENG ZHANG, MIN LIN, CHAO JI, TING GONG},
TITLE = {Thioredoxin domain-containing protein 9 protects cells against UV-B-provoked apoptosis via NF-κB/p65 activation in cutaneous squamous cell carcinoma},
JOURNAL = {Oncology Research},
VOLUME = {31},
YEAR = {2023},
NUMBER = {1},
PAGES = {71--82},
URL = {http://www.techscience.com/or/v31n1/51755},
ISSN = {1555-3906},
ABSTRACT = {Cutaneous squamous cell carcinoma (cSCC), a type of non-melanoma skin cancer (NMSC), is the most
common malignancy worldwide. Thioredoxin (TXN) domain-containing protein 9 (TXNDC9) is a member of the
TXN family that is important in cell differentiation. However, the biological function of this protein in cancer,
particularly cSCC, is still unknown. In the present study, our experiments revealed the protective effects of TXNDC9
on UV-B-irritated cSCC cells. The initial findings showed that TXNDC9 is significantly upregulated in cSCC tissue
and cells compared to normal skin tissue and keratinocytes. UV-B radiation robustly induces the expression of
TXNDC9, and UV-B-induced cSCC cell death is boosted by TXNDC9 deficiency. Moreover, cSCC cells lacking
TXNDC9 displayed attenuated activation of the NF-κB pathway. Additional studies by inhibiting TXNDC9 confirmed
this finding, as TXNDC9 deficiency attenuated UV-B radiation-induced translocation of NF-κB p65 from the
cytoplasm to the nucleus of cSCC. In conclusion, our work demonstrates the biological roles of TXNDC9 in cSCC
progression and may provide a novel therapeutic target to treat cSCC in the future.},
DOI = {10.32604/or.2022.028075}
}