TY  - EJOU
AU  - SHI, XINRUI 
AU  - GAO, XIA 
AU  - LIU, WENCONG 
AU  - TANG, XUEJIAO 
AU  - LIU, JIAYI 
AU  - PAN, DONGCHEN 
AU  - DUAN, XUEQING 
AU  - JIN, YUQING 
AU  - REN, WEIYAN 
AU  - YANG, LEI 
AU  - LIU, WENXUAN 

TI  - Construction of the panoptosis-related gene model and characterization of tumor microenvironment infiltration in hepatocellular carcinoma
T2  - Oncology Research

PY  - 2023
VL  - 31
IS  - 4
SN  - 1555-3906

AB  - Hepatocellular carcinoma (HCC) is the most common fatal cancer worldwide, patients with HCC have a high
mortality rate and poor prognosis. PANoptosis is a novel discovery of programmed cell death associated with cancer
development. However, the role of PANoptosis in HCC remains obscure. In this study, we enrolled 274 PANoptosisrelated genes (PANRGs) and screened 8 genes to set up a prognostic model. A previous scoring system calculated
PANscore was utilized to quantify the individual risk level of each HCC patient, and the reliability of the prognostic
model has been validated in an external cohort. Nomogram constructed with PANscore and clinical characteristics
were used to optimize individualized treatment for each patient. Single-cell analysis revealed a PANoptosis model
associated with tumor immune cell infiltration, particularly natural killer (NK) cells. Further exploration of hub genes
and assessment of the prognostic role of these 4 hub genes in HCC by quantitative real-time PCR (qRT-PCR) and
immunohistochemistry (IHC). In conclusion, we evaluated a PANoptosis-based prognostic model as a potential
prognostic biomarker for HCC patients.
KW  - PANoptosis
KW  -  Hepatocellular carcinoma
KW  -  Prognosis
KW  -  Single-cell analysis
KW  -  Immune infiltration

DO  - 10.32604/or.2023.028964