TY  - EJOU
AU  - ZHANG, LEI 
AU  - ZHANG, YUAN 
AU  - GAO, HUIJUAN 
AU  - LI, XIN 
AU  - LI, PEIFENG 

TI  - Underlying mechanisms and clinical potential of circRNAs in glioblastoma
T2  - Oncology Research

PY  - 2023
VL  - 31
IS  - 4
SN  - 1555-3906

AB  - Glioblastoma (GBM) is the most malignant form of glioma and is difficult to diagnose, leading to high mortality rates. Circular RNAs (circRNAs) are noncoding RNAs with a covalently closed loop structure. CircRNAs are involved in various pathological processes and have been revealed to be important regulators of GBM pathogenesis. CircRNAs exert their biological effects by 4 different mechanisms: serving as sponges of microRNAs (miRNAs), serving as sponges of RNA binding proteins (RBPs), modulating parental gene transcription, and encoding functional proteins. Among the 4 mechanisms, sponging miRNAs is predominant. Their good stability, broad distribution and high specificity make circRNAs promising biomarkers for GBM diagnosis. In this paper, we summarized the current understanding of the characteristics and action mechanisms of circRNAs, illustrated the underlying regulatory mechanisms of circRNAs in GBM progression and explored the possible diagnostic role of circRNAs in GBM.
KW  - CircRNAs; GBM; Underlying mechanisms; Clinical value

DO  - 10.32604/or.2023.029062