@Article{or.2023.042228,
AUTHOR = {ABHISHEK WAHI, MAMTA BISHNOI, NEHA RAINA, MEGHNA AMRITA SINGH, PIYUSH VERMA, PIYUSH KUMAR GUPTA, GINPREET KAUR, HARDEEP SINGH TULI, MADHU GUPTA},
TITLE = {Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment},
JOURNAL = {Oncology Research},
VOLUME = {32},
YEAR = {2024},
NUMBER = {1},
PAGES = {19--47},
URL = {http://www.techscience.com/or/v32n1/54646},
ISSN = {1555-3906},
ABSTRACT = {Cancer is a leading cause of death globally, with limited treatment options and several limitations.
Chemotherapeutic agents often result in toxicity which long-term conventional treatment. Phytochemicals are natural
constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents
providing alternative therapeutic approaches to minimize the resistance. These phytoconstituents act in several ways
and deliver optimum effectiveness against cancer. Nevertheless, the effectiveness of phyto-formulations in the
management of cancers may be constrained due to challenges related to inadequate solubility, bioavailability, and
stability. Nanotechnology presents a promising avenue for transforming current cancer treatment methods through
the incorporation of phytochemicals into nanosystems, which possess a range of advantageous characteristics such as
biocompatibility, targeted and sustained release capabilities, and enhanced protective effects. This holds significant
potential for future advancements in cancer management. Herein, this review aims to provide intensive literature on
diverse nanocarriers, highlighting their applications as cargos for phytocompounds in cancer. Moreover, it offers an
overview of the current advancements in the respective field, emphasizing the characteristics that contribute to
favourable outcomes in both in vitro and in vivo settings. Lastly, clinical development and regulatory concerns are
also discussed to check on the transformation of the concept as a promising strategy for combination therapy of
phytochemicals and chemotherapeutics that could lead to cancer management in the future.},
DOI = {10.32604/or.2023.042228}
}