@Article{or.2023.046174,
AUTHOR = {QIUQIANG CHEN, XIAOLEI ZHAO, WENXUE MA},
TITLE = {Game-changing insights on vertebral skeletal stem cells in bone metastasis and therapeutic horizons},
JOURNAL = {Oncology Research},
VOLUME = {32},
YEAR = {2024},
NUMBER = {1},
PAGES = {95--98},
URL = {http://www.techscience.com/or/v32n1/54649},
ISSN = {1555-3906},
ABSTRACT = {Greenblatt and his team have unveiled vertebral skeletal stem cells (vSSCs) as a critical player in the landscape
of bone metastasis. This commentary delves into the transformative discoveries surrounding vSSCs, emphasizing their
distinct role in bone metastasis compared to other stem cell lineages. We illuminate the unique properties and
functions of vSSCs, which may account for the elevated susceptibility of vertebral bones to metastatic invasion.
Furthermore, we explore the exciting therapeutic horizons opened by this newfound understanding. These include
potential interventions targeting vSSCs, modulation of associated signaling pathways, and broader implications for the
treatment and management of bone metastasis. By shedding light on these game-changing insights, we hope to pave
the way for novel strategies that could revolutionize the prognosis and treatment landscape for cancer patients with
metastatic bone disease.},
DOI = {10.32604/or.2023.046174}
}