TY  - EJOU
AU  - ZHANG, YUN 
AU  - TANG, SHALING 
AU  - GAO, YUBO 
AU  - LU, ZHONGTING 
AU  - YANG, YUAN 
AU  - CHEN, JING 
AU  - LI, TAO 

TI  - Application of exosomal miRNA mediated macrophage polarization in colorectal cancer: Current progress and challenges
T2  - Oncology Research

PY  - 2024
VL  - 32
IS  - 1
SN  - 1555-3906

AB  - Colorectal cancer (CRC) is a major global health problem with high morbidity and mortality rates. Surgical resection is the main treatment for early-stage CRC, but detecting it early is challenging. Therefore, effective therapeutic targets for advanced patients are still lacking. Exosomes, tiny vesicles in body fluids, play a crucial role in tumor metastasis, immune regulation, and drug resistance. Interestingly, they can even serve as a biomarker for cancer diagnosis and prognosis. Studies have shown that exosomes can carry miRNA, mediate the polarization of M1/M2 macrophages, promote the proliferation and metastasis of cancer cells, and affect the prognosis of CRC. Since the gastrointestinal tract has many macrophages, understanding the mechanism behind exosomal miRNA-mediated macrophage polarization in CRC treatment is crucial. This article summarizes recent advancements in the study of exosomal miRNAs in CRC and their potential as diagnostic and prognostic markers.
KW  - Colorectal cancer; Exosomes; microRNA; Macrophages; Treatment

DO  - 10.32604/or.2023.043481