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Metformin promotes anti-tumor immunity in STK11 mutant NSCLC through AXIN1-dependent upregulation of multiple nucleotide metabolites

ZHIGUO WANG1,2,#, KUNLIN LI2,#, CONGHUA LU2, MINGXIA FENG2, CAIYU LIN2, GUOFANG YIN1, DAN LUO1, WENYI LIU3, KAIYU JIN4, YUANYAO DOU2, DI WU2, JIE ZHENG2, KEJUN ZHANG5, LI LI2,*, XIANMING FAN1,*

1 Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China
2 Department of Respiratory Disease, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China
3 Department of Trauma Medical Center, Daping Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing, 400042, China
4 Department of Respiratory Disease, People’s Hospital of Xuyong County, Luzhou, 646000, China
5 Department of Outpatients, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China

* Corresponding Authors: LI LI. Email: email; XIANMING FAN. Email: email
# These authors contributed equally to the study

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