TY  - EJOU
AU  - WADHWA, KARAN 
AU  - CHAUHAN, PAYAL 
AU  - KUMAR, SHOBHIT 
AU  - PAHWA, RAKESH 
AU  - VERMA, RAVINDER 
AU  - GOYAL, RAJAT 
AU  - SINGH, GOVIND 
AU  - SHARMA, ARCHANA 
AU  - RAO, NEHA 
AU  - KAUSHIK, DEEPAK 

TI  - Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier
T2  - Oncology Research

PY  - 2024
VL  - 32
IS  - 5
SN  - 1555-3906

AB  -  <b>Background:</b> Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. <b>Objective:</b> Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. <b>Methods:</b> Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases, for example, PubMed, Science Direct, Google Scholar, and others, using specific keyword combinations, including “glioblastoma,” “brain tumor,” “nanocarriers,” and several others. <b>Conclusion:</b> This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM management. Elucidation of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.
KW  - Glioblastoma; Brain tumor; Blood-brain barrier; Liposomes; Metallic nanoparticles; Nanocarriers

DO  - 10.32604/or.2024.047278