TY  - EJOU
AU  - LIU, ZIYONG 
AU  - MA, TAO 
AU  - LI, JINFANG 
AU  - REN, WEI 
AU  - ZHANG, ZHIXIN 

TI  - IL13RA2 promotes progression of infantile haemangioma by activating glycolysis and the Wnt/β-catenin signaling pathway
T2  - Oncology Research

PY  - 2024
VL  - 32
IS  - 9
SN  - 1555-3906

AB  -  <b>Background:</b> Interleukin 13 receptor subunit alpha 2 (IL13RA2) plays an essential role in the progression of many cancers. However, the role of IL13RA2 in infantile haemangioma (IH) is still unknown. <b>Materials and Methods:</b> IL13RA2 expression in IH tissues was analyzed using western blot, qRT-PCR, and immunofluorescence. The role of IL13RA2 in haemangioma-derived endothelial cells (HemECs) was determined following knockdown or overexpression of IL13RA2 using CCK-8, colony formation, apoptosis, wound healing, tubule formation, Transwell, and western blot. <b>Results:</b> IL13RA2 expression was upregulated in IH tissues. IL13RA2 overexpression promoted proliferation, migration, and invasion of HemECs and induced glycolysis, which was confirmed with a glycolysis inhibitor. Specifically, IL13RA2 interacted with β-catenin and activated the Wnt/β-catenin pathway in HemECs, which were involved in the above-mentioned effects of IL13RA2. <b>Conclusions:</b> These findings revealed that targeting IL13RA2 is a potential therapeutic approach for IH.
KW  - Infantile haemangioma; IL13RA2; Glycolysis; Wnt/β-catenin pathway

DO  - 10.32604/or.2024.048315