@Article{or.2024.050835,
AUTHOR = {LIANGJIANG XIA, GUANGBIN LI, QINGWU ZHOU, YU FENG, HAITAO MA},
TITLE = {CircRNA circ_0015278 induces ferroptosis in lung adenocarcinoma through the miR-1228/P53 axis},
JOURNAL = {Oncology Research},
VOLUME = {33},
YEAR = {2025},
NUMBER = {2},
PAGES = {465--475},
URL = {http://www.techscience.com/or/v33n2/59301},
ISSN = {1555-3906},
ABSTRACT = { <b>Background:</b> Circular RNAs play an important role in regulating lung adenocarcinoma (LUAD). Bioinformatics analysis identified circ_0015278 as differentially expressed in LUAD. However, the biological mechanism of circ_0015278 in LUAD has not been fully clarified, especially in ferroptosis. <b>Materials and Methods:</b> Bioinformatics analysis was employed to explore the downstream mechanisms of Circ_0015278, subsequently confirmed by luciferase reporter assays. The impact of Circ_0015278 on cell proliferation, migration, invasion, and ferroptosis was investigated through a loss-of-function experiment. A xenotransplantation mouse model elucidated the effect of Circ_0015278 on tumour growth. <b>Results:</b> Circ_0015278 exhibited downregulation in LUAD. It inhibited cell proliferation, migration, and invasion while promoting ferroptosis by interacting with miR-1228 to regulate P53 expression through a competitive endogenous RNA mechanism. Moreover, circ_0015278 suppressed tumour growth in mice. <b>Conclusions:</b> Circ_0015278 was identified as a novel factor promoting ferroptosis in LUAD. Furthermore, it suppressed the malignant progression of LUAD through the miR-1228/P53 axis.},
DOI = {10.32604/or.2024.050835}
}