TY  - EJOU
AU  - ZHAO, SHUANG 
AU  - WEN, HONGYONG 
AU  - WANG, BAIQI 
AU  - XIONG, QINGLIN 
AU  - LI, LANXIN 
AU  - CHENG, AILAN 

TI  - p53: A player in the tumor microenvironment
T2  - Oncology Research

PY  - 2025
VL  - 33
IS  - 4
SN  - 1555-3906

AB  - 
Approximately half of all cancers have p53 inactivating mutations, in addition to which most malignancies inactivate the p53 pathway by increasing p53 inhibitors, decreasing p53 activators, or inactivating p53 downstream targets. A growing number of researches have demonstrated that p53 can influence tumor progression through the tumor microenvironment (TME). TME is involved in the process of tumor development and metastasis and affects the clinical prognosis of patients. p53 participates in host immunity and engages in the immune landscape of the TME, but the specific mechanisms remain to be investigated. This review briefly explores the interactions between different states of p53 and TME components and their mechanisms, as well as their effects on tumor progression. To understand the progress of drug development and clinical studies related to p53 and tumor microenvironment.
KW  - Tumor microenvironment (TME); p53; Wild type p53; Mutant p53; Cancer therapy

DO  - 10.32604/or.2025.057317