TY  - EJOU
AU  - ANCHONDO, GAVIN M. 
AU  - PARKER, KYRA 
AU  - BRUCE, ALEXIS 
AU  - CORTEZ, ELIZABETH 
AU  - SU, LE 

TI  - The SS18-SSX fusion oncoprotein: Friend and foe in targeted therapy for synovial sarcoma
T2  - Oncology Research

PY  - 2025
VL  - 33
IS  - 5
SN  - 1555-3906

AB  - Synovial sarcoma is a high-grade soft tissue malignancy characterized by a unique fusion gene known as SS18-SSX. The SS18-SSX fusion protein acts as an oncogenic driver of synovial sarcoma, and it has thus been commonly accepted that disruption of SS18-SSX function represents a therapeutic means of treating synovial sarcoma, but emerging evidence suggests that upon depletion of SS18-SSX, an anti-apoptotic signal surprisingly arises to protect synovial sarcoma cell survival. In this article, we discuss the controversial roles of SS18-SSX’s transcriptional activity in synovial sarcoma biology and outline a synergistic strategy for overcoming the resistance of synovial sarcoma cells to SS18-SSX targeted therapeutics.
KW  - SS18-SSX; Synovial sarcoma; Targeted therapy

DO  - 10.32604/or.2025.060573