TY  - EJOU
AU  - Cheng, Andong 
AU  - Chen, Yiding 
AU  - Li, Hao 
AU  - Yang, Feixiang 
AU  - Jiang, Junlan 
AU  - Tai, Sheng 
AU  - Chen, Weiwei 
AU  - Guan, Yu 
AU  - Yin, Shuiping 
AU  - Meng, Jialin 

TI  - Rare Multiple Brain Metastases Following Debulking Surgery and Androgen Deprivation Therapy in Aggressive Prostate Cancer-Case Report
T2  - Oncology Research

PY  - 2026
VL  - 34
IS  - 2
SN  - 1555-3906

AB  -  <b>Background:</b> In clinical practice, approximately 80% of prostate cancer (PC) cases are localized and can achieve favorable outcomes with appropriate treatment. Conversely, some remaining cases exhibit an aggressive phenotype or develop resistance to therapeutic interventions, leading to tumor metastasis and a poorer prognosis. When PC metastasizes to distant sites, the bone remains the predominant location, and brain metastases are regarded as exceedingly rare. <b>Case Description:</b> The current study focused on a rare clinical PC case that presented multiple brain metastases after prostate surgery. The patient was initially diagnosed with PC through prostate biopsy and subsequently underwent prostate debulking surgery while continuing androgen deprivation therapy, which maintained low prostate-specific antigen (PSA) levels for 4 years. However, a sudden PSA surge to 7.858 ng/mL led to the emergence of two brain metastatic tumors, which were confirmed to have originated from the prostate. <b>Conclusions:</b> Patients with advanced PC require comprehensive evaluations to detect rare metastatic sites, such as the brain, to avoid missed diagnoses. For patients with brain metastases, a multimodal approach combining surgical resection, postoperative radiotherapy, and endocrine therapy can effectively alleviate symptoms and enhance survival.
KW  - Prostate cancer; brain metastases; metastatic prostate cancer; castration-resistant prostate cancer; case report

DO  - 10.32604/or.2025.066478