@Article{or.2025.069397,
AUTHOR = {Yen-Cheng Chen, Tsung-Kun Chang, Wei-Chih Su, Yung-Sung Yeh, Po-Jung Chen, Tzu-Chieh Yin, Ching-Chun Li, Ching-Wen Huang, Hsiang-Lin Tsai, Jaw-Yuan Wang},
TITLE = {Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Locally Advanced Rectal Cancer Treated with Neoadjuvant Concurrent Chemoradiotherapy and Robotic-Assisted Resection},
JOURNAL = {Oncology Research},
VOLUME = {34},
YEAR = {2026},
NUMBER = {3},
PAGES = {--},
URL = {http://www.techscience.com/or/v34n3/66259},
ISSN = {1555-3906},
ABSTRACT = { <b>Background:</b> The long-term outcomes of robotic-assisted surgery and the prognostic significance of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in locally advanced rectal cancer (LARC) remain uncertain. This study aimed to assess the long-term outcomes of patients with LARC undergoing robotic-assisted surgery and to determine the prognostic value of pretreatment NLR. <b>Methods:</b> We retrospectively reviewed 252 patients with LARC who were treated at a single medical center in Taiwan between January 2012 and January 2023. All patients underwent neoadjuvant concurrent chemoradiotherapy (CRT) followed by robotic-assisted surgery with total mesorectal excision (TME). Patients were stratified into four groups on the basis of pretreatment NLRs and carcinoembryonic antigen (CEA) levels. Univariate and multivariate analyses were conducted to identify prognostic indicators for overall survival (OS) and disease-free survival (DFS). <b>Results:</b> Patients with a pretreatment NLR of ≥3.2 exhibited significantly worse OS and DFS compared with those with an NLR of &lt;3.2 (OS: 94.4 vs. 116.5 months, <i>p</i> = 0.001; DFS: 78.8 vs. 101.7 months, <i>p</i> = 0.003). Group A exhibited the poorest prognosis, whereas Group D had the most favorable outcomes. Multivariate analysis revealed NLR ≥ 3.2 as an independent predictor of poor OS (hazard ratio [HR] = 2.306, 95% CI: 1.149–3.747; <i>p</i> = 0.001) and DFS (HR = 2.055, 95% CI: 1.341–3.148; <i>p</i> = 0.001). <b>Conclusion:</b> Neoadjuvant concurrent CRT followed by robotic-assisted TME is an effective treatment strategy for LARC. A higher pretreatment NLR (≥3.2) independently predicted worse OS and DFS. Stratification using the NLR in combination with CEA levels may enhance prognostic accuracy for patients undergoing robotic-assisted surgery for LARC.},
DOI = {10.32604/or.2025.069397}
}