TY  - EJOU
AU  - He, Chang 
AU  - Wang, An 
AU  - Wang, Youbo 
AU  - Ma, Qinyun 
AU  - Chen, Xiaofeng 

TI  - Nanoliposome-Encapsulated Semiconductor Particles and Arsenic Trioxide Synergistically Enhance Chemo-Photothermal Therapy for Lung Cancer
T2  - Oncology Research

PY  - 2026
VL  - 34
IS  - 4
SN  - 1555-3906

AB  -  <b>Objectives:</b> Combined chemotherapy and photothermal therapy (PTT) represents a promising approach for enhancing cancer treatment efficacy. This study aimed to develop arsenic trioxide (ATO) and poly(cyclopentadithiophene-alt-benzothiadiazole) (PCPDTBT)-loaded nanoparticles (ATO/PCPDTBT@NPs) to evaluate their synergistic efficacy in inhibiting lung cancer growth and metastasis. <b>Methods:</b> Nanovesicles were synthesized via a streamlined protocol and subjected to 808 nm NIR irradiation to assess their photothermal conversion capabilities. The therapeutic efficacy was evaluated <i>in vitro</i> using A549 lung carcinoma cells to assess apoptosis, invasion, and migration, and <i>in vivo</i> to monitor tumor volume reduction. <b>Results:</b> The nanoparticles exhibited excellent hemocompatibility and low cytotoxicity while demonstrating robust photothermal conversion, inducing a rapid 20.8°C temperature rise within five minutes. <i>In vitro</i>, ATO enhanced apoptotic pathways and suppressed metastasis, while the combination therapy significantly reduced cell viability (OD: 0.23 vs. 0.62 in controls) and migration (13.6% vs. 74.9%), outperforming monotherapies. <i>In vivo</i>, the chemo-photothermal treatment reduced tumor volumes by 2.5- and 3-fold compared to ATO or PTT alone, confirming superior antitumor effects. <b>Conclusions:</b> These findings highlight the dual-action ATO/PCPDTBT@NPs nanoplatform as a potential multifaceted strategy for effective tumor suppression and metastasis inhibition.
KW  - Arsenic trioxide (ATO); poly(cyclopentadithiophene-alt-benzothiadiazole) (PCPDTBT); lung cancer; liposomes; tumor metastasis

DO  - 10.32604/or.2026.074880