@Article{or.2026.073081,
AUTHOR = {Haojie Yang, Zicong Tan, Zihao Liu, Kang Chen, Ning Liufu, Fengtao Ji},
TITLE = {Circ72688 Drives Breast Cancer Invasion and Metastasis via the miR-654-5p/ORAI2 Axis},
JOURNAL = {Oncology Research},
VOLUME = {34},
YEAR = {2026},
NUMBER = {5},
PAGES = {--},
URL = {http://www.techscience.com/or/v34n5/67045},
ISSN = {1555-3906},
ABSTRACT = { <b>Background:</b> Circular RNAs (circRNAs) play a crucial role in the progression of malignant tumors such as breast cancer. <b>Methods:</b> A circRNA microarray was used to detect key circRNAs in breast cancer. Expression of Circ72688 was verified by quantitative reverse transcription PCR (qRT-PCR) and fluorescence <i>in situ</i> hybridization (FISH) assay. Transwell assay and <i>in vivo</i> assay were conducted to prove the function of Circ72688. Exploring the downstream mechanism, dual-luciferase reporter assay, western blotting, and tissue microarray were performed. <b>Results:</b> We sequenced and identified a circRNA, hsa-circ-0072688, also known as Circ72688. Our research found that Circ72688 enhanced tumor metastasis both <i>in vivo</i> and <i>in vitro</i>. Mechanistically, Circ72688 acted as a molecular sponge for hsa-miR-654-5p, thereby affecting the transcription of ORAI2. The expression levels of Circ72688 and ORAI2 were significantly higher in breast cancer tissues compared to adjacent normal tissues, and a notable positive correlation could be seen between them. <b>Conclusions:</b> In summary, our study demonstrated the critical role of Circ72688 in breast cancer invasion and metastasis, and how Circ72688 partially regulated ORAI2 through hsa-miR-654-5p. Targeting Circ72688 might be a potential therapeutic strategy for breast cancer.},
DOI = {10.32604/or.2026.073081}
}