TY  - EJOU
AU  - Alvarez, Leonardo Daniel Villalana 
AU  - García-Campoy, Abraham Heriberto 
AU  - Muñiz-Ramirez, Alethia 

TI  - Antiglycation, Antioxidant, and Antidiabetic Effects of <i>Ibervillea sonorae</i> (Wereke) in a Diabetic Zebrafish Model
T2  - Phyton-International Journal of Experimental Botany

PY  - 
VL  - 
IS  - 
SN  - 1851-5657

AB  - Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia, oxidative stress, and the formation of advanced glycation end products (AGEs). This study examined the antiglycation, antioxidant, and antidiabetic properties of the methanolic extract of <i>Ibervillea sonorae</i> (IsM). Antiglycation activity was assessed <i>in vitro</i> using a bovine serum albumin–glucose model, and the antidiabetic effects were evaluated using a zebrafish model of experimentally induced hyperglycemia. Gas chromatography–mass spectrometry (GC–MS) analysis revealed several metabolites, including fatty acids and phytosterols. The extract significantly inhibited AGEs formation <i>in vitro</i> and reduced AGEs accumulation in the ocular tissue of diabetic zebrafish. <i>In vivo</i> treatment significantly decreased blood glucose, triglyceride, and cholesterol levels compared to diabetic controls. IsM also modulated oxidative stress by increasing reduced glutathione (GSH) levels and the activity of antioxidant enzymes (GPx, SOD, and CAT), while decreasing malondialdehyde levels in blood and gill tissues. These results suggest that the extract has protective effects through modulation of oxidative stress and inhibition of protein glycation. While these results demonstrate the therapeutic potential of <i>Ibervillea sonorae</i>, additional research is necessary to isolate the bioactive compounds and elucidate the molecular mechanisms underlying the observed biological effects.
KW  - Diabetes mellitus; oxidative stress; zebrafish model; advanced glycation end products; phytochemicals; Wereke

DO  - 10.32604/phyton.2026.085201