TY  - EJOU
AU  - Ammari, Aiman 
AU  - Amran, Ramzi 
AU  - Alhimaidi, Ahmad 

TI  - Exploring the Therapeutic Potential of <i>Horwoodia dicksoniae</i> through Phytochemical Profiling, Antioxidant Assessment, and Biological Activity Evaluation
T2  - Phyton-International Journal of Experimental Botany

PY  - 
VL  - 
IS  - 
SN  - 1851-5657

AB  - Medicinal plants are valuable sources of bioactive compounds with diverse pharmacological properties. However, the phytochemical composition and biological activities of <i>Horwoodia dicksoniae</i> remain insufficiently investigated. Therefore, this study evaluated the phytochemical composition, antioxidant activity, physicochemical characteristics, and <i>in vitro</i> cytotoxic potential of the ethanolic extract of <i>H. dicksoniae</i> collected from the Thumamah area, Riyadh, Saudi Arabia. The extract was subjected to phytochemical characterization, chemical profiling, physicochemical analysis, antioxidant activity assessment, and cytotoxicity evaluation. Qualitative screening confirmed the presence of phenolics, flavonoids, tannins, terpenoids, and glycosides, while quantitative analysis revealed high levels of phenolic and tannin constituents. The extract exhibited notable antioxidant activity, with half-maximal inhibitory concentration (IC<sub>50</sub>) values of 500.65 ± 2.54 and 227.52 ± 6.85 μg/mL. Chemical profiling identified 127 phytochemical constituents, predominantly fatty acids, terpenoids, esters, and oxygenated hydrocarbons, with 9,12-octadecadienoic acid (Z,Z)-, cis-(-)-1,2-epoxy-p-menth-8-ene, n-hexadecanoic acid, caryophyllene oxide, phytol, linalool, and retinol as the major compounds. Physicochemical analysis indicated satisfactory dispersion stability, while cytotoxicity testing against A549 cells demonstrated moderate growth inhibition, although the IC<sub>50</sub> value was not reached within the tested concentration range. These findings suggest that <i>H. dicksoniae</i> is a promising source of bioactive phytochemicals with antioxidant potential and warrants further investigation for pharmaceutical applications.
KW  - Phytochemical profiling; FTIR spectroscopy; antioxidant activity; cytotoxicity; medicinal plants

DO  - 10.32604/phyton.2026.087258