@Article{phyton.2026.085064,
AUTHOR = {Taras Koliadzhyn, Andriy Grytsyk, Nadiia Lehin, Lubov Grytsyk, Ain Raal, Oleh Koshovyi},
TITLE = {Phytochemical Profiling and Pharmacological Evaluation of <i>Astrantia major</i> L. Herb Extracts with Systemic Anti-Inflammatory and Topical Hemostatic, Wound-Healing, and Antimicrobial Activities},
JOURNAL = {Phyton-International Journal of Experimental Botany},
VOLUME = {},
YEAR = {},
NUMBER = {},
PAGES = {{pages}},
URL = {http://www.techscience.com/phyton/online/detail/27911},
ISSN = {1851-5657},
ABSTRACT = {<i>Astrantia major</i> L. (Apiaceae) is a non-official medicinal plant with a long history of use in the traditional medicine of many European countries; however, its phytochemical composition and pharmacological properties remain insufficiently studied. This study aimed to investigate the phenolic profile of <i>A. major</i> herb extracts and evaluate their biological activities. A total of 17 phenolic compounds were identified, including hydroxycinnamic acids, flavonoids, catechins and tannin-related metabolites. Chlorogenic acid was the predominant hydroxycinnamic acid, while rutin was the major flavonoid. Among the tannin-related metabolites, gallocathechin predominated in the aqueous extract (AM0), whereas epigallocatechin was the major constituent in the hydroethanolic extract (AM70). The total phenolic content ranged from 14.42 ± 0.13% to 16.91 ± 0.09%. Pharmacological evaluation of aqueous and 70% hydroethanolic extracts demonstrated statistically significant anti-inflammatory activity compared to the pathological control group, reduced bleeding time, and accelerated wound healing. The extracts also exhibited selective antimicrobial activity against <i>Staphylococcus epidermidis and Escherichia coli</i>. The selectivity pattern differed between the extracts. The observed biological activities are likely correlated with the phenolic profile of the plant. <i>A. major</i> represents a promising source of biologically active compounds with hemostatic, wound-healing, and anti-inflammatory potential.},
DOI = {10.32604/phyton.2026.085064}
}