@Article{phyton.2018.87.068,
AUTHOR = {Chel-Guerrero LD, R Gómez-Cansino, SL Gúzman-Gutierrez, MG Campos-Lara, E Saury-Duch, F Díaz de León Sánchez, R Reyes-Chilpa, JA Mendoza-Espinoza},
TITLE = {<i>In vitro</i> antiviral activity and phytochemical screen in the extracts of peels from four species of tropical fruits collected in Merida Yucatan, Mexico},
JOURNAL = {Phyton-International Journal of Experimental Botany},
VOLUME = {87},
YEAR = {2018},
NUMBER = {all},
PAGES = {68--71},
URL = {http://www.techscience.com/phyton/v87nall/33924},
ISSN = {1851-5657},
ABSTRACT = {The objective of this study was to investigate extracts
from the peels of <i>Annona squamosa</i> L. (purple sugar apple), <i>Annona
reticulata</i> L. (custard apple), <i>Chrysophyllum cainito</i> L. (green
star apple), and <i>Melicoccus bijugatus</i> Jacq. (mamoncillo), as potential
sources of anti-HIV-1 agents. Methanolic extracts from the peels
of the aforementioned tropical fruits were obtained by maceration.
Antiviral activity was evaluated through HIV-1 RT inhibition by
extracts, using a non-radioactive immuno/colorimetric assay (Lenti
RT Activity Assay, Cavidi Tech). Assay was performed according to
the protocol provided by the manufacturer. Extracts from the peels
of <i>A. squamosa, A. reticulata</i>, and <i>C. cainito</i> showed high antiviral activity,
with HIV-1 reverse transcriptase inhibition values of 96.45 ±
2.08%, 78.63 ± 0.97%, and 72.55 ± 2.26%, respectively. These results
demonstrate that <i>A. squamosa, A. reticulata</i>, and <i>C. cainito</i> have significant
antiviral activity in their peels and can therefore be regarded
as potential sources of anti-HIV-1 agents.},
DOI = {10.32604/phyton.2018.87.068}
}