@Article{phyton.2020.07665,
AUTHOR = {Aknur Turgumbayeva, Gulbaram Ustenova, Ubaidilla Datkhayev, Khairolla Rahimov, Silvijus Abramavicius, Agile Tunaityte, Kairat Zhakipbekov, Kaldanay Kozhanova, Saken Tulemissov, OzikhanUstenova, Gulmira Datkayeva, Edgaras Stankevicius},
TITLE = {Safflower (Carthamus Tinctorius L.) a Potential Source of Drugs against Cryptococcal Infections, Malaria and Leishmaniasis},
JOURNAL = {Phyton-International Journal of Experimental Botany},
VOLUME = {89},
YEAR = {2020},
NUMBER = {1},
PAGES = {137--146},
URL = {http://www.techscience.com/phyton/v89n1/38407},
ISSN = {1851-5657},
ABSTRACT = {In this research we present that <i>Carthamus Tinctorius</i> L. (gen. 
Asteraceae, otherwise known as Safflower) (Fig. 1) may contain agents active in 
Cryptococcal infections, malaria and Leishmaniasis, as treatment options are 
becoming scarce due to drug resistance development. Phytochemistry and 
pharmacological activities (antimicrobial, antimalarial, antileishmanial) of C. <i>tinctorius</i> L. were analyzed. The composition of volatile oil of safflower dried 
flowers was analyzed by gas chromatography-mass spectrophotometry with 
flame ionization detector (GC-FID) and in vitro sensitivity assays were 
performed to assess biological activity. 8 known and 3 unknown compounds 
were detected in the extract (Fig. 1). Then the Safflower ointment was 
manufactured and its acute toxicity study on rats was tested. The volatile oil of <i>C.
tinctorius</i> L exhibited activity against <i>Cryptococcus neoformans</i>, <i>Plasmodium 
falciparum</i> and <i>Leishmania donovani</i>. Safflower volatile oil has anticryptococcal,
antimalarial and antileishmanial effects. The prepared ointment had an excellent 
acute toxicity safety profile.},
DOI = {10.32604/phyton.2020.07665}
}