TY  - EJOU
AU  - Vinyagam, Ramachandran 
AU  - Kumar, Pradeep 
AU  - Lee, Kyung Eun 
AU  - Xu, Baojun 
AU  - Matin, Muhammad Nurul 
AU  - Kang, Sang Gu 

TI  - Biological and Functional Properties of Wedelolactone in Human Chronic Diseases
T2  - Phyton-International Journal of Experimental Botany

PY  - 2021
VL  - 90
IS  - 1
SN  - 1851-5657

AB  - Medicinal herbs are well known and studied over the past millennia in most of the developing countries as a rational means of treatment against various diseases and disorders. Wedelolactone (WDL), a major bioactive compound in <i>Eclipta prostrata</i> L (<i>Eclipta alba</i> L), has been reported with potential benefits in human health against chronic diseases. However, a comprehensive study on WDL pharmacological benefits in various ailments, to the best of our knowledge, is not yet reported. Thereof, the present review provides the recent therapeutic applications in reference to biological and functional activities against major human chronic diseases, including cardiovascular, cancer, diabetes mellitus, liver disease, Alzheimer’s disease, and androgenetic alopecia. In this study, we collected all the relevant experimental information on WDL from Scientific databases such as PubMed, Web of Science, Science Direct, and Google Scholar. Conclusively, WDL is recognized as a key anti-oxidant with both specific regulator and inhibitor of major drug targetable proteins in human chronic diseases and disorders. Hence, WDL as a novel therapeutic bioactive molecule is advised to explore further for relevant pharmacological activities.
KW  - Wedelolactone; <i>Eclipta alba</i> L; <i>Ecliptaprostrata</i> L; bioactivity; bioavailability

DO  - 10.32604/phyton.2020.013388