@Article{phyton.2021.013305,
AUTHOR = {Suzana Vieira Rabêlo, Fernanda Granja da Silva Oliveira, Michele Miriam Calixto de Lira, Livia Macedo Dutra, Adilson Sartoratto, Marta Cristina Teixeira Duarte, Maria Claudia dos Santos Luciano, Maria Francilene Souza Silva, Cláudia do Ó Pessoa, Manoel Odorico de Moraes Filho, Emmanoel Vilaça Costa, Jackson Roberto Guedes da Silva Almeida},
TITLE = {Non-Polar Chemical Constituents of Atemoya and Evaluation of the Cytotoxic and Antimicrobial Activity},
JOURNAL = {Phyton-International Journal of Experimental Botany},
VOLUME = {90},
YEAR = {2021},
NUMBER = {3},
PAGES = {921--931},
URL = {http://www.techscience.com/phyton/v90n3/41939},
ISSN = {1851-5657},
ABSTRACT = {This study aimed to identify the chemical composition of essential oil from fruits (EOAF) and the hexanic crude
extract from aerial parts (At-Hex) of atemoya (<i>Annona cherimola</i> x <i>Annona squamosa</i>), a hybrid belonging to the
Annonaceae family. Cytotoxic and antimicrobial activity was also evaluated. OEAF was obtained by hydrodistillation using a Clevenger apparatus, and their composition was analyzed by gas chromatography-mass spectrometry
(GC-MS) analyses. Cytotoxicity was tested against human tumor cell lines HCT-116 (colon carcinoma), SF-295
(glioblastoma), OVCAR-8 (ovarian carcinoma) and HL60 (leukemia) using 3-(4,5-dimethyl-2-thiazolyl)-2,5-
diphenyl-2H-tetrazolium bromide (MTT) assay, while antimicrobial activity was conducted by bioauthography
method against eleven microorganisms strains. Twenty-four compounds were identified in the EOAF and
twenty-nine in At-Hex. The monoterpenes linalool (25.70%), α-pinene (10.38%), β-pinene (9.12%), transocimene (7.43%), and the sesquiterpene bicyclogermacrene (12.58%) were the major constituents of EOAF,
whereas the sesquiterpene spathulenol (13.91%) was the main compound of At-Hex. At-Hex showed a high
cytotoxicity against SF-295 (glioblastoma). These findings show an important chemotaxonomic contribution
for the Annonaceae family, mainly for the <i>Annona</i> genus. Atemoya proved to be a promising source of substances
with potential cytotoxic activity.},
DOI = {10.32604/phyton.2021.013305}
}