@Article{phyton.2022.020295,
AUTHOR = {Lingdi Liu, Chunxiu Wen, Wei Tian, Xiaoliang Xie, Saiqun Wen, Tao Jiang},
TITLE = {Metabolomics Analysis of Metabolites in <i>Forsythia suspense</i> Fruit Using UPLC/ESI-Q TRAP-MS/MS},
JOURNAL = {Phyton-International Journal of Experimental Botany},
VOLUME = {91},
YEAR = {2022},
NUMBER = {10},
PAGES = {2313--2330},
URL = {http://www.techscience.com/phyton/v91n10/48003},
ISSN = {1851-5657},
ABSTRACT = {Forsythiae Fructus, the fruit of <i>Forsythia suspense</i> is a traditional Chinese hebal medicine that has the antiviral
and antioxidant effects in China. Modern analytical chemistry studies showed that the extracts of Forsythiae Fructus contain many bioactive components, such as flavonoids, lignans, phenolic acids, and terpenoids, which can be
used to anti-inflammatory and treat toxicity, tonsillitis, ulcers, pharyngitis and acute nephritis. In order to study
the types and quantities of metabolites in Forsythiae Fructus, we isolated, identified and analysed metabolites
between two varieties of Forsythiae Fructus using UPLC/ESI-Q TRAP-MS/MS. The results showed that a total
of 407 metabolites were identified in Forsythiae Fructus using UPLC/ESI-Q TRAP-MS/MS, including 21 terpenoids, 68 phenolic acids, 63 flavonoids, 43 amino acids and derivatives, 22 alkaloids, 55 lipids, 24 lignans and
coumarins, 31 nucleotides and derivatives, 29 organic acids, and 51 other metabolites. Among, lignans and coumarins, terpenoids, organic acids, lipids, and phenolic acids were rich in Forsythiae Fructus, which accounted for
more than 60% of the total metabolite content. Differential metabolite analysis revealed that 80 metabolites differed significantly between the two types of Forsythiae Fructus. Our results greatly enrich the Forsythiae Fructus
phytochemical composition database and provide valuable information for further study of the metabolites of
Forsythiae Fructus.},
DOI = {10.32604/phyton.2022.020295}
}