TY  - EJOU
AU  - Koshovyi, Oleh 
AU  - Sepp, Janne 
AU  - Jakštas, Valdas 
AU  - Žvikas, Vaidotas 
AU  - Tolmacheva, Karina 
AU  - Kireyev, Igor 
AU  - Heinämäki, Jyrki 
AU  - Raal, Ain 

TI  - Phytochemical and Pharmacological Study on the Dry Extract of <i>Matricaria discoidea</i> DC. herb and Its Amino Acids Preparations
T2  - Phyton-International Journal of Experimental Botany

PY  - 2024
VL  - 93
IS  - 11
SN  - 1851-5657

AB  - Pineappleweed (<i>Matricaria discoidea</i> DC., Asteraceae) herb is an essential oil containing raw material with spasmolytic and anti-inflammatory activity. It is also rich in phenolics, which may be used in pharmaceutical practice. This study aimed to investigate the phenolic and amino acid composition and the hyporific and analgesic effects of the <i>M. discoidea</i> aqueous-ethanolic extract and its amino acid modifications. In addition, we developed a polyethylene oxide gel formulation with <i>M. discoidea</i> extracts for the 3D-printed oral solid dosage preparations. In <i>M. discoidea</i> extracts, 16 phenolic substances and 14 amino acids were established. The extract and its amino acid preparations revealed both analgesic and soporific activity in the studies with rodents. Amino acids enhanced these effects. Arginine, β-alanine, glycine, valine, and lysine potentiated the analgesic activity by 27%–64%, while β-alanine, glycine, and valine increased the soporific activity by 136%, 176%, and 129%, respectively. The composition of the polyethylene oxide (PEO) printing gel with the <i>M. discoidea</i> extract was developed, and its printability was confirmed. The proposed 3D-printed medicines could be implemented for sleep disorders and painful conditions.
KW  - Pineapple weed; herb; extract; polyphenolics; amino acids; analgesic activity; soporific activity; 3D printing

DO  - 10.32604/phyton.2024.056536