@Article{phyton.2025.059581,
AUTHOR = {Yan Wu, Xuerui An, Haofan Lv, Zhiqiang Zhao, Wei Liu, Chunpeng Wan},
TITLE = {One Novel Nortriterpenoid from the Mastic (<i>Pistacia lentiscus</i>) and Its Anti-Inflammatory Activity},
JOURNAL = {Phyton-International Journal of Experimental Botany},
VOLUME = {94},
YEAR = {2025},
NUMBER = {1},
PAGES = {199--207},
URL = {http://www.techscience.com/phyton/v94n1/59344},
ISSN = {1851-5657},
ABSTRACT = {
A novel pair of oleanane nor-triterpenes, with compound <b>1</b> featuring a unique 18<i>α</i>-H structure, was isolated from mastic, and this compound represents a noteworthy new entity not previously reported in the literature. The absolute configurations of their structures were further determined using a combination of different analytical methods such as NMR, high-resolution mass spectrometry (HR-MS), ultraviolet (UV), infrared (IR) and single-crystal X-ray diffraction (SXRD). The compound actively mitigated inflammations by efficiently quenching nitric oxide (NO) synthesis within an <i>ex vivo</i> system using lipopolysaccharide activated murine macrophage RAW264.7 cells. Moreover, compound <b>1</b> exhibit a better IC<sub>50</sub> concentration of 11.69 ± 1.39 <i>µ</i>M, surpassing the efficacy of the positive control dexamethasone, which exhibited an IC<sub>50</sub> of 23.21 ± 1.17 <i>μ</i>M. While compound <b>2</b> also demonstrated inhibitory activity, its potency was comparatively weaker, with an IC<sub>50</sub> of 26.18 ± 2.66 <i>μ</i>M.},
DOI = {10.32604/phyton.2025.059581}
}