TY  - EJOU
AU  - Wu, Yan 
AU  - An, Xuerui 
AU  - Lv, Haofan 
AU  - Zhao, Zhiqiang 
AU  - Liu, Wei 
AU  - Wan, Chunpeng 

TI  - One Novel Nortriterpenoid from the Mastic (<i>Pistacia lentiscus</i>) and Its Anti-Inflammatory Activity
T2  - Phyton-International Journal of Experimental Botany

PY  - 2025
VL  - 94
IS  - 1
SN  - 1851-5657

AB  - 
A novel pair of oleanane nor-triterpenes, with compound <b>1</b> featuring a unique 18<i>α</i>-H structure, was isolated from mastic, and this compound represents a noteworthy new entity not previously reported in the literature. The absolute configurations of their structures were further determined using a combination of different analytical methods such as NMR, high-resolution mass spectrometry (HR-MS), ultraviolet (UV), infrared (IR) and single-crystal X-ray diffraction (SXRD). The compound actively mitigated inflammations by efficiently quenching nitric oxide (NO) synthesis within an <i>ex vivo</i> system using lipopolysaccharide activated murine macrophage RAW264.7 cells. Moreover, compound <b>1</b> exhibit a better IC<sub>50</sub> concentration of 11.69 ± 1.39 <i>µ</i>M, surpassing the efficacy of the positive control dexamethasone, which exhibited an IC<sub>50</sub> of 23.21 ± 1.17 <i>μ</i>M. While compound <b>2</b> also demonstrated inhibitory activity, its potency was comparatively weaker, with an IC<sub>50</sub> of 26.18 ± 2.66 <i>μ</i>M.
KW  - Mastic; nor-triterpene; 18<i>α</i>-H oleanane; anti-inflammatory

DO  - 10.32604/phyton.2025.059581