@Article{phyton.2025.071525,
AUTHOR = {Qinfu Sun, Junqiang Xing, Wanyu Zhang, Chen Lin},
TITLE = {Beyond Photomorphogenesis: Multifaceted Roles of BBX Transcription Factors in Plant Stress Responses and Breeding Perspectives},
JOURNAL = {Phyton-International Journal of Experimental Botany},
VOLUME = {94},
YEAR = {2025},
NUMBER = {11},
PAGES = {3349--3370},
URL = {http://www.techscience.com/phyton/v94n11/64699},
ISSN = {1851-5657},
ABSTRACT = {Extensive transcriptomic reprogramming is triggered by biotic and abiotic stresses in plants, with coordinated regulation mediated through multiple transcription factor families, such as WRKY, MYB, NAC, and BBX proteins. Among these, B-box (BBX) proteins represent a distinct class of zinc finger transcription factors characterized by the presence of conserved B-box domains. They serve as central regulators in plant photomorphogenesis and developmental processes. Accumulating genetic and biochemical evidence demonstrates that BBX family members orchestrate plant responses to biotic and abiotic stresses through multifaceted molecular mechanisms, including the regulation of reactive oxygen species (ROS) homeostasis, enhancement of anthocyanin biosynthesis, and modulation of hormonal signaling pathways. This review systematically summarizes recent advances in the identification of BBX family genes in different plant species. Furthermore, their emerging roles in mediating plant stress responses are elucidated, with molecular mechanisms being comprehensively analyzed at both transcriptional and post-translational levels. However, to fully harness the potential of BBX genes in crop improvement, a deeper understanding of their functional mechanisms including BBX-mediated hormonal crosstalk networks, growth–defense trade-offs, and more extensive field performance data remains essential. These insights provide a theoretical foundation for developing climate-resilient crop varieties through targeted genetic improvement strategies.},
DOI = {10.32604/phyton.2025.071525}
}