@Article{phyton.2026.077998,
AUTHOR = {Saleh Al-Maaqar, Bassam Al-Johny, Majed Al-Shaeri, Lara Al-Johny, Adel Qumusani, Zakia Albalawy, Djadjiti Namla},
TITLE = {Phytochemical Landscape of <i>Coleus forskohlii</i> and Its Role in Countering Staphylococcus Species},
JOURNAL = {Phyton-International Journal of Experimental Botany},
VOLUME = {95},
YEAR = {2026},
NUMBER = {4},
PAGES = {--},
URL = {http://www.techscience.com/phyton/v95n4/67204},
ISSN = {1851-5657},
ABSTRACT = {Staphylococcal meningitis, a severe infection of the meninges, highlights the urgent need for new strategies to combat <i>Staphylococcus aureus</i> (<i>S. aureus</i>) infections. In this study, ethanolic leaf extracts of <i>Coleus forskohlii</i> were evaluated for their antibacterial potential against clinical <i>S. aureus</i> isolates associated with meningitis. Gas chromatography-mass spectrometry (GC-MS) analysis identified 15 phytochemical compounds, two of which—urs-12-en-28-ol (CID 22213452) and petroselaidic acid (CID 5282754) showed promising binding affinities (−7.5 and −5.9 kcal/mol, respectively) against <i>S. aureus</i> protein (30S ribosomal subunit) in molecular docking studies. <i>In vitro</i> assays confirmed the antibacterial activity of the crude extract, with a minimum inhibitory concentration (MIC) ranging from 62.5 to 125 μg/mL. Disc diffusion and time-kill kinetics further demonstrated concentration-dependent growth inhibition of <i>S. aureus</i> strains. These integrated findings suggest that <i>C. forskohlii</i>-derived compounds are potential antibacterial candidates worthy of further investigation. However, comprehensive <i>in vivo</i> studies are essential to evaluate their efficacy, safety, and therapeutic potential specifically against <i>S. aureus</i>-induced meningitis.},
DOI = {10.32604/phyton.2026.077998}
}