Marta Fogeda, Luis Gallart, Cristina Gutiérrez, Joan Vendrell, Inmaculada Simón, Antonio García-España, Cristóbal Richart
European Cytokine Network, Vol.15, No.1, pp. 60-66, 2004
Abstract The tumor necrosis factor system plays an important role in the pathogenesis of obesity and type
2 diabetes (DM), by a complex and only partially understood mechanism. In this study we analyze the mRNA
expression levels of TNFα and its receptors (TNFR1 and TNFR2), in peripheral blood mononuclear cells (PBMC)
from eleven, non-morbid, obese and 14, obese, type 2 DM women, by real-time quantitative PCR. We show an
increase in the TNFR2 to TNFR1 ratio (mTNFR2/mTNFR1) in type 2 DM (r = 0.63; p = 0.021, after adjusting for
age). Likewise, a positive correlation between… More >