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  • Open Access

    ABSTRACT

    The Effect of the Elongation of the Proximal Aorta on the Estimation of Aortic Wall Distensibility

    Stamatia Pagoulatou1,*, Mauro Ferraro1, Bram Trachet1,2, Georgios Rovas1, Vasiliki Bikia1, Dionysios Adamopoulos3, Lindsey Crowe3, Jean-Paul Vallée3, Nikolaos Stergiopulos1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 148-149, 2019, DOI:10.32604/mcb.2019.07346

    Abstract This article has no abstract. More >

  • Open Access

    ABSTRACT

    Rationally Designed Synthetic Protein Hydrogels with Predictable and Controllable Mechanical Properties

    Ying Li1, Bin Xue2, Wenxu Sun2, Junhua Wu2, Wenting Yu2, Meng Qin2, Wei Wang2, Yi Cao2,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 147-147, 2019, DOI:10.32604/mcb.2019.07027

    Abstract A key challenge in biomaterials research is to produce synthetic hydrogels that can replicate the diverse mechanical properties of the naturally occurring tissues for various biomedical applications, including tissue engineering, stem cell and cancer research, cell therapy, and immunomodulation. However, currently, the methods that can be used to control the mechanical properties of hydrogels are very limited and are mainly focused only on the elasticity of hydrogels. In this work, combining single molecule force spectroscopy, protein engineering and theoretical modeling, we show that synthetic protein hydrogels with predictable mechanical properties can be rationally designed using… More >

  • Open Access

    ABSTRACT

    Microspheres Modified with the Heparin Increasing the Length of Molecular Linker to Better Capture the Endotoxin

    Qi Dang1, Chun-Gong Li1, Xin-Xin Jin1, Ya-Jin Zhao1, Xiang Wang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 146-146, 2019, DOI:10.32604/mcb.2019.07074

    Abstract Endotoxin is a a very powerful and toxic inflammatory stimulator usually leading to the sepsis occurred. In order to remove endotoxin better through hemoperfusion, it is a pretty choice to increase the length of molecular linker on adsorbents. In this study, we chose the heparin as a molecular linker because of its being anticoagulant linear polysaccharide. Heparin as a linker was covalently immobilized on the chloromethylated polystyrene microspheres (Ps) and then connected with L-phenylalanine (Phe) forming the Ps-Hep-Phe structure to adsorbed endotoxin better. The property of microspheres was characterized by Fourier transform infrared spectroscopy, X-ray More >

  • Open Access

    ABSTRACT

    The Mechanical Mechanism of Cortical Folding on 3D Cerebral Organoids

    Zongkun Hou1, Shilei Hao1, Bochu Wang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 145-145, 2019, DOI:10.32604/mcb.2019.07077

    Abstract An expansion of the cerebral neocortex is thought to be the foundation for the unique intellectual abilities of humans. The cortical folding has been implicated in neurodevelopmental disorders and yet its origins remain unknown. In vitro culture of 3D cerebral organoids from human pluripotent stem cells has been used to study the fundamental mechanisms of mammalian neurodevelopment and characteristics of human brain development. Here, we explores the mechanism of boundary limitation on the formation of gyri and sulci through the self-organization of human brain organoids. The structure of cerebral organoids was analyzed by morphology observation, pathology… More >

  • Open Access

    ABSTRACT

    The Rate of Fluid Shear Stress is a Potent Regulator for Lineage Commitment of Mesenchymal Stem Cells Through Modulating [Ca2+]i, F-actin and Lamin A

    Danyang Yue1, Yijuan Fan1, Juan Lu1, Mengxue Zhang1, Jin Zhou1, Yuying Bai1, Jun Pan1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 144-144, 2019, DOI:10.32604/mcb.2019.07084

    Abstract Mesenchymal Stem Cells (MSCs) are recruited to the musculoskeletal system following trauma [1] or chemicals stimulation [2]. The regulation of their differentiation into either bone or cartilage cells is a key question. The fluid shear stress (FSS) is of pivotal importance to the development, function and even the repair of all tissues in the musculoskeletal system [3]. We previously found that MSCs are sensitive enough to distinguish a slight change of FSS stimulation during their differentiation commitment to bone or cartilage cells, and the internal mechanisms. In detail, MSCs were exposed to laminar FSS linearly… More >

  • Open Access

    ABSTRACT

    A New Mass Effect Research Rat Model to Explore the Occuping Effect on Secondary Brain Injuries after ICH

    Yuhua Gong1, Shilei Hao1,*, Bochu Wang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 143-143, 2019, DOI:10.32604/mcb.2019.07095

    Abstract The mechanical response of brain tissue closely relates to cerebral blood flow and brain diseases. During intracerebral haemorrhage (ICH), a mass effect occurs during the initial bleeding. As the hematoma increases, the haematoma mass effect continues to squeeze the brain tissue mechanically, which can even lead to the formation of fatal cerebral hernia. However, fewer studies have focused on the brain damage mechanisms and treatment approaches associated with mass effects compared to the secondary brain injuries after ICH, which may be a result of the absence of acceptable animal models mimicking a mass effect. Thus,… More >

  • Open Access

    ABSTRACT

    Oscillatory Shear Stress Induces Endothelial Dysfunction through the Activation of P2Y12

    Jianxiong Xu1, Lu Wang1, Jinxuan Wang1, Juhui Qiu1,*, Guixue Wang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 142-142, 2019, DOI:10.32604/mcb.2019.07273

    Abstract Endothelial cell injured or dysfunction, which results lipid deposition and inflammation, is the key point to exacerbate the process of atherosclerosis [1, 2]. Meanwhile oscillatory shear stress is a key factor that results cell dysfunction in vascular disease [3, 4]. Previous research reported that P2Y12 plays a critical role in the development of atherosclerotic lesion through promoting smooth muscle cells migration [5]. As well P2Y12 stimulated the internalization and transendothelial transport of high density lipid. However, whether the P2Y12 induce atherosclerosis through endothelial cell remain elusive. In this study we firstly found P2Y12 were expressed… More >

  • Open Access

    ABSTRACT

    Endothelial Tight Junction Protein ZO-1 Response to Multiple-Mechanical Stimulations After Stent Implamtation

    Yang Wang1, Shuang Ge1, Junyang Huang1, Ruolin Du1, Tieying Yin1, Guixue Wang1,*, Yazhou Wang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 140-141, 2019, DOI:10.32604/mcb.2019.07300

    Abstract Zonula occludens-1 (ZO-1) is a peripheral membrane protein belongs to the family of zona occludens proteins and plays an important role as a scaffold protein which cross-links and anchors tight junction (TJ) strand proteins, within the lipid bilayer, to the actin cytoskeleton[1-2]. Stent implantation is the most effective method in the treatment of cardiovascular disease which always destroy junctions of endothelial cells, the functions of the tight junction were also affected. However, the role of ZO-1 before and after stent implantation has not been fully understood. In this study, the expression of ZO-1 were analyzed by… More >

  • Open Access

    ABSTRACT

    Expression of Endothelial Tight Junction Protein Occludin under Mechanical Factors after Stent Implantation

    Junyang Huang1, Shuang Ge1, Yang Wang1, Ruolin Du1, Yazhou Wang1, Tieying Yin1, Guixue Wang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 138-139, 2019, DOI:10.32604/mcb.2019.07305

    Abstract Tight junctions are the most apical intercellular junctions of the lateral membrane in endothelial cells, regulating the paracellular material and energy exchange and maintain plasma membrane polarity. Occludin protein is one of the important proteins involved in endothelial tight junctions, and also closely related to the occurrence of atherosclerosis. Therefore, the study of occludin is valuable [1]. With the implantation of coronary stents, the integrity of the vascular endothelium is damaged and the local mechanical environment at the stent segment was changed [2]. The present study tried to explore the impact of mechanical stimulation after stent… More >

  • Open Access

    ABSTRACT

    Mechano Growth Factor (MGF) Expression and Response to Multiple-Mechanical Stimulation after Biodegradable Stent Implantation

    Shuang Ge1, Ruolin Du1, Yuhua Huang1, Guixue Wang1, Yazhou Wang1, Tieying Yin1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 136-137, 2019, DOI:10.32604/mcb.2019.07317

    Abstract Stent implantation is the most effective method in the treatment of cardiovascular disease which always destroy the integrity of the vascular endothelium and the local mechanical environment at the stent segment was changed, especially the biodegradable stents [1]. In this study, 3D printed biodegradable poly (L-lactic acid) stents were implanted into SD rat abdominal aorta and the endothelialization, intimal hyperplasia, and MGF after stent implantation were studied. Besides, based on the MGF we explored the effects of mechanical stimulation on MGF express in vascular endothelial cells and smooth muscle cells, and also the effects of… More >

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