Zhiyong Li^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 29-30, 2019, DOI:10.32604/mcb.2019.06308

Abstract In this article, we summarize our previous work in imaging-based computational modelling and simulation of the interaction between blood flow and atherosclerotic plaque. We also discussed our recent developments in multiphysical modelling of plaque progression and destabilization. Significance and translation of the modelling study to clinical practice are discussed in order to better assess plaque vulnerability and accurately predict a possible rupture. More >

Peng Wu^1,*, Qi Gao², Runjie Wei³, Hongping Wang³, Lizhong Wang³

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 27-28, 2019, DOI:10.32604/mcb.2019.05711

Abstract Cardiovascular diseases are the leading cause of human deaths worldwide. Traditional diagnostic tools of cardiovascular diseases are either based on 2D static medical images, or invasive, bringing troubles to both patients and doctors. Our team is committed to the development of image-based non-invasive diagnostic system for cardiovascular diseases. We have made progress mainly in the following areas: 1) 4D flow technology for heart and large blood vessels. According to MRI 4D Flow data, three-dimensional velocity fields within blood vessels were constructed. Divergence-fee smoothing (DFS) was proposed to eliminate the high frequency noise in the hemodynamic… More >

Fuyou Liang^1,*, Tianqi Wang¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 25-26, 2019, DOI:10.32604/mcb.2019.05710

Abstract Hepatic venous pressure gradient (HVPG) measurement has been increasingly accepted as a useful means for indirectly measuring portal venous pressure in patients with portal hypertension (PHT) caused by chronic liver diseases. Despite the existence of numerous studies addressing the clinical utility of HVPG measurement, it is as yet unclear how the accuracy of measured HVPG as a surrogate of portal pressure gradient (PPG) is influenced by the pathological status of the hepatic circulation that not only changes with the progression of liver disease but also differs considerably among patients. In addition, it remains unclear whether… More >

Haibo Jia^1,*, Bo Yu¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 23-24, 2019, DOI:10.32604/mcb.2019.05708

Abstract Coronary angiography is the traditional standard imaging modality for visual evaluation of coronary anatomy and guidance of percutaneous coronary interventions (PCI). However, the 2-dimensional lumenogram cannot depict the arterial vessel per se and plaque characteristics, or directly assess the stenting result. Intracoronary imaging by means of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) provides valuable incremental information that can be used clinically to optimize stent implantation and thereby minimize stent-related problems. Beyond guidance of stent selection and optimisation, imaging provides critical insights into the pathophysiology of acute coronary syndrome (ACS), greater clarity when confronted… More >

Zhuangyuan Meng¹, Tao Ma², Shengzhang Wang^1,*, Zhihui Dong^2,*, Weiguo Fu²

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 19-21, 2019, DOI:10.32604/mcb.2019.05706

Abstract This article has no abstract. More >

Stéphane Avril^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 17-18, 2019, DOI:10.32604/mcb.2019.05705

Abstract The fluid mechanics community has been interested for many years in hemodynamics. More recently, significant endeavours of the solid mechanics community have permitted to establish constitutive equations and to achieve stress analyses in arterial lesions (atheromatous plaque in coronary or carotid arteries, aneurysms of the aorta). The mechanical properties of blood vessels have often been characterized ex vivo, but medical imaging, including MRI, now allows non-intrusive identifications in vivo. The spatial heterogeneity of these mechanical properties, even at the macroscopic scale, remains poorly explored despite its undeniable interest in understanding the mechanisms of remodeling and degeneration of… More >

Shengxian Tu^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 15-16, 2019, DOI:10.32604/mcb.2019.05704

Abstract Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. It is the disease of the blood vessels supplying the heart muscle. The fatty plaques built within the walls of the coronary arteries might rupture, creating a thrombus, thereby blocking the entire flow through the vessel, which is followed by a heart attack. Patients who suffer from CAD with documented ischemia are predominately sent to the catheterization laboratory for an invasive procedure (PCI, or percutaneous coronary intervention) to open the vessel by the placement of a “stent” as a scaffolding device to… More >

Kairong Qin^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 13-14, 2019, DOI:10.32604/mcb.2019.05703

Abstract Common carotid arteries (CCAs) are the major arteries supplying blood to the brain, and the hemodynamic variables in which are closely associated with the cardiovascular diseases. Exercise can induce the hemodynamic responses in the CCAs, including variations in blood pressure, circumferential stretch, and wall shear stress (WSS). Mechanosensors in the endothelial cells (ECs) are able to sense and distinguish these variations as mechanical signals, and transmit them into the interior of cells to affect cellular morphology and gene expression. Notably, reasonable exercises improve arterial structure and function, while unreasonable exercises cause endothelial dysfunction. Therefore, studies… More >

Dalin Tang^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 11-11, 2019, DOI:10.32604/mcb.2019.05170

Abstract Medical imaging and image-based modeling have made considerable progress in recent years in cardiovascular research, such as identifying atherosclerotic plaque morphological and mechanical risk factors which may be used in developing improved patient screening strategies, and performing virtual heart surgery seeking optimal surgical procedures for best post-surgical outcome. We will report recent progress in using multi-modality image-based models to predict vulnerable plaque progression and vulnerability change. In particular, we will report our recent results using IVUS+OCT data to obtain more accurate stress/strain calculations. Inflammation and cap erosion will affect cap material properties. If OCT image… More >

Shaoxiong Yang¹, Xiaobo Gong^1,*, Yingxin Qi², Zonglai Jiang²

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 9-10, 2019, DOI:10.32604/mcb.2019.05701

Abstract Blood vessels interact with their mechanical environments in a comprehensive way. Local mechanical stimuli outside the biological range play important roles in various human cardiovascular diseases. Although many mechanobiological studies of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) in vitro have been reported in mimicking cellular dysfunctions, their quantitative correlations to the in vivo vascular conditions remain unclear. In order to interpret the stress-modulated dysfunctions of vascular cells and explore the key mechanical factors in vascular diseases, it is important to investigate the mechanical environments of vessel walls in vivo under various physiological conditions. Based on… More >