Colonel David G. McLeod

Canadian Journal of Urology, Vol.25, No.2, pp. 9221-9227, 2018

Abstract This article has no abstract. More >

Leonard G. Gomella

Canadian Journal of Urology, Vol.25, No.2, pp. 9220-9220, 2018

Abstract This article has no abstract. More >

Albert S. Lee¹, Diana K. Bowen², Seth Vatsky³, Stephen A. Zderic², Gregory E. Tasian²

Canadian Journal of Urology, Vol.25, No.3, pp. 9363-9365, 2018

Abstract We report successful percutaneous nephrolithotomy (PCNL) in an 8-week-old, 4.12 kg infant with a combined stone burden of > 2 cm in a solitary kidney. The patient was born with thoracolumbar myelomeningocele and had developed recurrent urinary tract infections. Her size precluded retrograde intrarenal surgery and shockwave lithotripsy would be unlikely to clear the stone burden. Stone analysis revealed hydroxyapatite and carbonate apatite stones, and metabolic work up revealed hypercalciuria for which chlorothiazide was started. To our knowledge, this is the youngest patient to undergo PCNL reported in the literature. More >

Ksenia Chezar¹, Geoffrey Gotto², Shaun Medlicott¹, Kiril Trpkov¹

Canadian Journal of Urology, Vol.25, No.3, pp. 9360-9362, 2018

Abstract The presence of urothelial epithelial metaplasia in a seminal vesicle is an exceptionally rare finding. We describe a unique case of urothelial metaplasia of the seminal vesicle and ejaculatory duct, found in a radical prostatectomy specimen from a patient with complex urogenital anatomy. A 70-year-old patient with organ confined (pT2) prostatic adenocarcinoma (Gleason score 3+4 = 7) had a right-sided Hutch diverticulum and a left crossed-fused renal ectopia. Although the histogenesis of urothelial metaplasia in the seminal vesicle remains unclear, in the patient presented herein it likely developed as a consequence of the previously unrecognized More >

Bradley A. Morganstern¹, Samantha Scaccia¹, Wayland Wu¹, Alex K. Williamson², Lane S. Palmer¹

Canadian Journal of Urology, Vol.25, No.3, pp. 9357-9359, 2018

Abstract Embryonal rhabdomyosarcoma is a rare cancer that often requires multimodality therapy to treat; however, these therapies can cause changes in the biology of the tumor. Several reports have documented pathologic changes but only recently have genetic changes been mapped. We present case of two separate synchronous primary rhabdomyosarcomas in a 17-month-old patient and discuss the pathophysiology and genetic changes that occur with treatment. We hypothesize that a genetic feld defect arising in development of the urogenital sinus caused the tumors, but that treatment modalities may have caused genetic alterations changing clinical behavior of the tumors More >

Vladimir Mouraviev¹, Michael McDonald²

Canadian Journal of Urology, Vol.25, No.3, pp. 9349-9356, 2018

Abstract Introduction: The changing face of current infection phenotypes — from planktonic to biofilm type — has increasingly implicated bacterial biofilms in recurrent infections. To date, no specific medical treatment exists that can effectively target biofilms within the human host. Similarly, the identification of biofilms has traditionally relied on tissue sample analysis using electron microscopy or DNA identification via polymerase chain reaction (PCR) and sequencing. Standard culture and sensitivity tests are not capable of detecting the presence of biofilms.
Materials and methods: Two types or "levels" of molecular microbial diagnostic testing were performed as described below. In both… More >

Avinash Chenam¹, Nora Ruel², Sumanta Pal³, John Barlog¹, Clayton Lau¹, Timothy Wilson¹, Bertram Yuh¹

Canadian Journal of Urology, Vol.25, No.3, pp. 9340-9348, 2018

Abstract Introduction: Extended lymph node dissection (ELND) compared to limited lymph node dissection (LLND) at the time of prostatectomy improves staging and lymph node (LN) yield. The effect on biochemical recurrence (BCR) and survival is less well understood. We sought to evaluate the benefit of robotic ELND and LLND with respect to BCR.
Materials and methods: Between 2008-2012, 584 consecutive men with intermediate or high-risk clinically localized adenocarcinoma of the prostate underwent robotic-assisted radical prostatectomy (RARP) with concomitant LLND (n = 326) or ELND (n = 258). Survival estimates were made using the Kaplan-Meier method. Log-rank statistic was… More >

Michael A. Avallone, Peter N. Dietrich, Shanta T. Shepherd, Mona Lalehzari, R. Corey O’Connor, Michael L. Guralnick

Canadian Journal of Urology, Vol.25, No.3, pp. 9334-9339, 2018

Abstract Introduction: Classic surgical teaching advocates for closure of the mesenteric defect (MD) after bowel anastomosis, but the necessity is controversial. We sought to evaluate the necessity of MD closure at the time of harvest of ileum for genitourinary reconstructive surgery (GURS) by analyzing the incidence of early and late gastrointestinal adverse events (GIAE) in patients with and without MD closure.
Materials and methods: A retrospective review was conducted on patients undergoing urologic reconstruction with ileum to identify incidence of ileus, small bowel obstruction (SBO), gastrointestinal (GI) fistula, and stoma complications. Patient and procedure variables were analyzed to… More >

Bradley A. Erickson¹, Brennan A. Tesdahl¹, Maria A. Voznesensky¹, Benjamin N. Breyer², Bryan B. Voelzke³, Nejd F. Alsikafi⁴, Alex J. Vanni⁵, Joshua A. Broghammer⁶, Jill C. Buckley⁷, Jeremy B. Myers⁸, William O. Brant⁸, Lee C. Zhao⁹, Thomas G. Smith III¹⁰, Brian L. Swick¹, Laila Dahmoush¹

Canadian Journal of Urology, Vol.25, No.3, pp. 9328-9333, 2018

Abstract Introduction: Given the poor understanding of the pathophysiology of genital lichen sclerosus (GLS) and a lack of accepted definitive diagnostic criteria, we proposed to survey pathologists regarding their understanding of GLS. We hypothesized that significant disagreement about GLS will exist.
Materials and methods: All urologists participating in the Trauma and Urologic Reconstruction Network of Surgeons identified genitourinary pathologists (GUP) and dermatopathologists (DP) at their respective institutions who were then invited to participate in an online survey regarding their experience with diagnosing GLS, GLS pathophysiology, and its relationship to urethral stricture disease.
Results: There were 23 (12 DP, 11… More >

S. Johar Raza¹, Perry Xu¹, Justin Barnes², Robert Fisher¹, Allison May¹, Oussama Darwish¹, Brian Dang¹, Prajakta Adsul¹, Carl A. Freeman³, Sameer A. Siddiqui¹

Canadian Journal of Urology, Vol.25, No.3, pp. 9323-9327, 2018

Abstract Introduction: Conservative management of penetrating renal trauma is emerging, with data originating from centers with variable levels of trauma care. This study reviews the outcomes of renal salvage after penetrating trauma at a level I trauma center.
Materials and methods: An institutional review board approved trauma registry at Saint Louis University Hospital was retrospectively analyzed for patients with penetrating renal trauma from 2009 to 2014. Patients were divided into nephrectomy group (NG) or non-nephrectomy group (non-NG), and compared. A multi-variable analysis was performed to determine predictors of nephrectomy, with cross-validation to evaluate the performance of the multi-variable… More >