Yang Li^1,*, Dongwei Yang¹, Jiangkun Zhang¹

Structural Durability & Health Monitoring, Vol.12, No.1, pp. 51-63, 2018, DOI:10.3970/sdhm.2018.012.051

Abstract Diffusion behavior of chloride ion in reinforced concrete under bending moment was studied by taking the ratio of bending moment to ultimate flexural capacity as load level indicator. The function relationship between load level and chloride ion diffusion coefficient was established, based on that the limit state equation of the chloride ion critical concentration and chloride ion concentration on surface of the steel bar was established. Then by applying Monte-Carlo method the corrosion probability of reinforcement under different load levels in splash zone was calculated. Calculation results demonstrated that compared with the durability reliability index More >

Licai Zhao^1,*, Shishuenn Chen

Structural Durability & Health Monitoring, Vol.12, No.1, pp. 35-50, 2018, DOI:10.3970/sdhm.2018.012.035

Abstract In the process of railway construction, because of the inconvenience of geological condition, water bursting and mud surging happen frequently, and the later deformation of support structure on the happening geology section would threaten the normal running of railway. The limit difference of deformation control value of the support structure section where geological accidents frequently happen, is small, and artificial half-automatic supervisory technology cannot get the health condition of tunnel in time, resulting many cars speed-down accidents due to deformation of support structure. Through design innovation, we introduce TGMIS in the later period of Yanzishan… More >

Zaitie Chen^1,*, Wei Wang², Dayang Li³

Structural Durability & Health Monitoring, Vol.12, No.1, pp. 19-33, 2018, DOI:10.3970/sdhm.2018.012.019

Abstract The distribution of many active faults in western China is an important reason for the frequent earthquakes. With the rapid development of the western region, many major projects have been built there and the existence of active faults is bound to have an influence on the safety of the engineering structure. Therefore, it is of great significance to study the mechanism of fault slip instability for evaluating the geological stability of the region and for the site selection of major projects. In this paper, cusp catastrophe theory is used to establish a cusp catastrophe model… More >

A. Kroworz¹, A. Katunin^1,*

Structural Durability & Health Monitoring, Vol.12, No.1, pp. 1-18, 2018, DOI:10.3970/sdhm.2018.012.001

Abstract Non-destructive testing (NDT) of structures is one of the most important tasks of the proper maintenance and diagnosis of machines and constructions structural condition. NDT methods contribute to the damage tolerance philosophy used in the aircraft design methodology as well as many other operation and maintenance programs of machinery and constructions. The following study is focusing on overviewing an important group of NDT methods: the optical and other ones, which found broad applicability in scientific and industrial studies nowadays. The paper discusses the selected most widely applicable methods, namely, visual testing, ultrasonic testing, radiographic testing, More >

Xiaozhong Chen^1,*, Zhijian Mao¹

Molecular & Cellular Biomechanics, Vol.15, No.4, pp. 229-241, 2018, DOI:10.32604/mcb.2018.03818

Abstract Shape optimization of orthopedic fixation plate is of great importance in the treatment of complex fracture. Therefore, a method in this paper to automatically optimize the complex shape of anatomical plate according to static analysis. Based on the theory of finite element analysis (FEA), our approach is processed as follows. First, the three-dimensional finite element model of the fracture fixation is constructed. Next, according to the type and feature of fracture, the anatomical plate was parameterized in two levels (the bounding surface and plate model). Then, parameter constraints are set up to meet the needs More >

Zahra Niki Boroujeni¹, Atefeh Shirkav¹, Seyed Ahmad Aleyasin^1,*

Molecular & Cellular Biomechanics, Vol.15, No.4, pp. 215-227, 2018, DOI:10.32604/mcb.2018.01813

Abstract Down syndrome critical region 1 gene (DSCR1) is an anti-angiogenesis gene that inhibits the growth of tumor cells. In this study, the role of autophagy and apoptosis in DSCR1-induced cytotoxicity were investigated in MDA-MB-468 breast cancer cells. Lentivirus vector harboring DSCR1 (LV-DSCR1⁺) was constructed in HEK 293 cells and the optimal dosage of lentivirus vector for infection was determined by the MTT assay. After infection of cells using LV-DSCR1⁺, acridine orange and ethidium bromide staining was performed to investigation of apoptosis and autophagy. Expression of DSCR1 and marker genes for angiogenesis (VEGF), apoptosis (Bax and Bcl2) and autophagy (LC3 More >

Junhao Yang¹, Chunxiao Chen^1,*, Qingyang Zang¹, Jianfei Li¹

Molecular & Cellular Biomechanics, Vol.15, No.4, pp. 203-214, 2018, DOI:10.32604/mcb.2018.03824

Abstract Pathological slide is increasingly applied in the diagnosis of breast tumors despite the issues of large amount of data, slow viewing and high subjectivity. To overcome these problems, a micrograph recognition method based on convolutional neural network is proposed for pathological slide of breast tumor. Combined with multi-channel threshold and watershed segmentation, a sample database including single cell, adhesive cell and invalid cell was established. Then, the convolution neural network with six layers is constructed, which has ability to classify the stained breast tumor cells with accuracy of more than 90%, and evaluate the proliferation More >

Qingyu Wang¹, Dalin Tang^1,2,*, Gador Canton³, Zheyang Wu², Thomas S. Hatsukami⁴, Kristen L. Billiar⁵, Chun Yuan⁶

Molecular & Cellular Biomechanics, Vol.15, No.4, pp. 189-201, 2018, DOI:10.32604/mcb.2018.04572

Abstract Cardiovascular diseases are closely linked to atherosclerotic plaque development and rupture. Assessment of plaque vulnerability is of fundamental significance to cardiovascular research and disease diagnosis, prevention, treatment and management. Magnetic resonance image (MRI) data of carotid atherosclerotic plaques from 8 patients (5 male, 3 female; age: 62-83, mean=71) were acquired at the University of Washington (UW), Seattle by the Vascular Imaging Laboratory (VIL) with written informed consent obtained. Patient-specific vessel material properties were quantified using Cine MRI data for modeling use. 3D thin-layer models were used to obtain plaque stress and strain for plaque assessment.… More >

Ruihan Zhang^1,2, Junhao Yang¹, Chunxiao Chen^1,*

Molecular & Cellular Biomechanics, Vol.15, No.3, pp. 177-187, 2018, DOI:10.3970/mcb.2018.04292

Abstract The proportion of cells staining for the nuclear antigen Ki-67 is an important predictive indicator for assessment of tumor cell proliferation and growth in routine pathological investigation. Instead of traditional scoring methods based on the experience of a trained laboratory scientist, deep learning approach can be automatically used to analyze the expression of Ki-67 as well. Deep learning based on convolutional neural networks (CNN) for image classification and single shot multibox detector (SSD) for object detection are used to investigate the expression of Ki-67 for assessment of biopsies from patients with breast cancer in this More >

Ying Mao¹, Chaojing Li¹, Peng Ge¹, Fujun Wang^1,*, Lu Wang^1,*

Molecular & Cellular Biomechanics, Vol.15, No.3, pp. 143-154, 2018, DOI:10.3970/mcb.2018.03987

Abstract Heparin/ PEG-PCL core-shell microcarriers were fabricated in one-step via coaxial-electrospraying technology. Optimization of the coaxial-electrospraying processing is by controlling the PEG-PCL concentration, applied voltage, receiving distance, and feed rate. The influence of the electrospray parameters on microsphere morphology was studied by optical microscopy and scanning electron microscopy. The functional groups and components of the electrosprayed microspheres were characterized by Fourier transform infrared spectroscopy (FTIR). Transmission electron microscope (TEM) observation proved the core-shell structure of heparin-loaded PEG-PCL microspheres. Drug loading and releasing study demonstrated that PEG-PCL concentration could control the encapsulation efficiency and releasing activity of More >