Weichen Hou^*, Lei Song^†, Yang Zhao^*, Qun Liu^*, Shuyan Zhang^‡

Oncology Research, Vol.25, No.1, pp. 43-53, 2017, DOI:10.3727/096504016X14719078133285

Abstract The role of miRNAs in the radiosensitivity of glioma cells and the underlying mechanism is still far from clear. In the present study, we detected six downregulated and seven upregulated miRNAs in the serum after radiotherapy compared with paired serum samples before radiotherapy via miRNA panel PCR. Among these, miR-17-5p was highly reduced (fold change = −4.21). Further, we validated the levels of miR-17-5p in all serum samples with qRT-PCR. In addition, statistical analysis suggested that a reduced miR-17-5P level was positively associated with advanced clinical stage of glioma, incidence of relapse, and tumor differentiation. More >

Hailin Pang¹, Ningqiang Ma¹, Mi Jiao, Weiwei Shen, Bo Xin, Tongfei Wang, Feng Zhang, Lili Liu, Helong Zhang

Oncology Research, Vol.25, No.1, pp. 35-42, 2017, DOI:10.3727/096504016X14719078133249

Abstract The bone is among the most common sites of metastasis in patients with lung cancer. Over 30%–40% of lung cancers can develop bone metastasis, and no effective therapeutic methods exist in clinic cases. Wnt/β-catenin signaling and Dickkopf1 (DKK1) play important roles in the progression of lung cancer, which preferentially metastasizes to the skeleton. However, the role of DKK1 in osteotropism of small cell lung cancer (SCLC) remains to be elucidated. This study aimed to define the role of DKK1 in SCLC bone metastasis and investigate the underlying mechanisms. Our results demonstrated that the expression level… More >

Hongyan Ge^*, Di Zou^†, Yingshu Wang^*, Hao Jiang^*, Liping Wang^‡

Oncology Research, Vol.25, No.1, pp. 29-34, 2017, DOI:10.3727/096504016X14719078133168

Abstract Aberrantly expressed microRNAs (miRNAs/miRs) and their role in cancer development have recently gained more attention. However, the potential role of miRNAs in hepatocellular carcinoma (HCC) remains largely unknown. In this study, we demonstrated that miR-377 was markedly downregulated in HCC cell lines and primary human HCC tissues. The decreased expression of miR-377 contributes to the upregulation of Bcl-xL expression by targeting its 3'-untranslated region (3'-UTR). Functionally, knockdown of miR-377 noticeably increased HCC cell growth and colony formation and inhibited apoptosis. In contrast, overexpression of miR-377 suppressed cell proliferation and increased apoptosis. This study provides new More >

Li Zhang^*, Hong-bin Duan^†, Yun-sheng Yang^*

Oncology Research, Vol.25, No.1, pp. 19-27, 2017, DOI:10.3727/096504016X14685034103914

Abstract Rap2B, a member of the Ras family of small GTP-binding proteins, was found to be highly expressed in various human tumors and plays an important role in the development of tumors. However, the function of Rap2B in hepatocellular carcinoma (HCC) remains unclear. Therefore, in this study, we investigated the biological functions of Rap2B in HCC and the potential underlying mechanisms. Our results indicated that Rap2B was highly expressed in HCC tissues and cell lines. Rap2B silencing obviously inhibited the proliferation, migration, and invasion of HCC cells, as well as attenuated xenografted tumor growth in vivo. More >

Yao Shi^*, Xiaoke Sun^†, Xiafen He^‡

Oncology Research, Vol.25, No.1, pp. 11-18, 2017, DOI:10.3727/096504016X14685034103833

Abstract Aristaless-like homeobox-4 (ALX4), a member of the Aristaless-like homeobox family, has been found to be involved in tumor cell proliferation, migration, and invasion. However, the role of ALX4 in hepatocellular carcinoma (HCC) remains largely unclear. Therefore, in this study we investigated the effects of ALX4 on HCC. The study results indicated that the expression of ALX4 was downregulated in HCC tissues and cell lines. Furthermore, we demonstrated that overexpression of ALX4 inhibited the proliferation, invasion, and epithelial–mesenchymal transition (EMT) in HCC cells. We also found that ALX4 had an inhibitory effect on the sonic hedgehog More >

Jianlin Wang^*1, Wenjie Song^*1, Weiwei Shen^†1, Xisheng Yang^*, Wei Sun^*, Sshibin Qu^*, Runze Shang^*, Ben Ma^*, Meng Pu^*, Kaishan Tao^*, Kefeng Dou^*, Haimin Li^*

Oncology Research, Vol.25, No.1, pp. 1-10, 2017, DOI:10.3727/096504016X14685034103798

Abstract MicroRNA-200a (miR-200a) is frequently downregulated in most cancer types and plays an important role in carcinogenesis and cancer progression. In this study, we determined that miR-200a was downregulated in hepatocellular carcinoma (HCC) tissues and cell lines, consistent with the results of our previous study. Because a previous study suggested that downregulation of miR-200a is correlated with HCC metastasis, we aimed to elucidate the mechanism underlying the role of miR-200a in metastasis in HCC. Here we observed that overexpression of miR-200a resulted in suppression of HCC metastatic ability, including HCC cell migration, invasion, and metastasis, in More >

Amir Faghri, Yuwen Zhang

Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-1, 2017, DOI:10.5098/hmt.8.41

Abstract This article has no abstract. More >

Chetteti RamReddy^a,†, Teegala Pradeepa^a

Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-10, 2017, DOI:10.5098/hmt.8.6

Abstract A numerical approach has been used to analyze the effects of homogeneous-heterogeneous reaction and nonlinear density temperature variation over a vertical plate in an incompressible micropolar fluid flow saturated Darcy porous medium. In addition, convective boundary condition is incorporated in a micropolar fluid model. The similarity representation for the set of partial differential equations is attained by applying Lie group transformations. The resulting non-dimensional equations are worked out numerically by spectral quasi-linearization method. Less temperature and wall couple stress coefficient, but more velocity, skin friction, species concentration, and heat transfer rate are noticed by enhancing More >

CH. Amanulla^a,b,* , N. Nagendra^a , M. Suryanarayana Reddy^b

Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-11, 2017, DOI:10.5098/hmt.8.40

Abstract A theoretical and computational study of the magneto hydrodynamic flow and free convection heat transfer in an electro-conductive polymer on the external surface of a vertical permeable cone under radial magnetic field is presented. Thermal and velocity (hydrodynamic) slip are considered at the vertical permeable cone surface via modified boundary conditions. The Williamson viscoelastic model is employed which is representative of certain industrial polymers. The non-dimensional, transformed boundary layer equations for momentum and energy are solved with the second order accurate implicit Keller box finite difference method under appropriate boundary conditions. Validation of the numerical… More >

Jadav Konch^*, G. C. Hazarika

Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-10, 2017, DOI:10.5098/hmt.8.39

Abstract This paper investigates momentum, heat and mass transfer characteristics of a hydromagnetic Newtonian dusty fluid flow due to a rotating disk with radiation and viscous dissipation. The main objective of this paper is to study effects of temperature dependent viscosity and thermal conductivity on flow, temperature and species concentration. Radiation and viscous dissipation effects are also taken into account. Saffman model for dusty fluid is considered for the problem. The partial differential equations governing the flow are converted into ordinary differential equations employing similarity transformations. The resulting highly nonlinear coupled ordinary differential equations are solved More >