E. P. Yalcintas¹, J. Hu¹, Y. Liu^1,2, A. Voloshin^1,2,3

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.2, pp. 151-180, 2014, DOI:10.3970/cmes.2014.098.151

Abstract Mechanical behavior of cells plays a crucial role in response to external stimuli and environment. It is very important to elucidate the mechanisms of cellular activities like spreading and alignment as it would shed light on further biological concepts. In this study, a multi-scale computational approach is adopted by modeling the cytoskeleton of cell as a tensegrity structure. The model is based on the complementary force balance between the tension and compression elements, resembling the internal structure of cell cytoskeleton composed of microtubules and actin filaments. The effect of surface topology on strain energy of… More >

J.B. Alford¹, D.C. Simkins¹, R.A. Rembert¹, L. Hoyte, MD²

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.2, pp. 129-149, 2014, DOI:10.3970/cmes.2014.098.129

Abstract Mechanical deformation of tissues in the female pelvic floor is believed to be central to understanding a number of important aspects of women’s health, particularly pelvic floor dysfunction. A 2008 study of US women reported the prevalence of pelvic floor disorders in the 20 and 39 years range as 9.7% with the prevalence increasing with age until it reaches roughly 50% in the 80 and older age group [Nygaard, Barber, Burgio, and et al (2008)]. Clinical observation indicates a strong correlation between problems such as pelvic organ prolapse/urinary incontinence and vaginal childbirth. It is thought… More >

Louis C. Foucard¹, John Pellegrino¹, Franck J. Vernerey^1,2

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.1, pp. 101-127, 2014, DOI:10.3970/cmes.2014.098.101

Abstract Many colloidal-sized particles encountered in biological and membranebased separation applications can be characterized as soft vesicles such as cells, yeast, viruses and surfactant micelles. The deformation of these vesicles is expected to critically affect permeation by accommodating pore shapes and sizes or enhancing the adhesion with a pore surface. Numerical and theoretical modelings will be critical to fully understand these processes and thus design novel filtration membranes that target, not only size, but deformability as a selection criterion. The present paper therefore introduces a multiscale strategy that enables the determination of the permeability of a… More >

Ankush Aggarwal¹, Jiun-Shyan Chen², William S. Klug³

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.1, pp. 69-99, 2014, DOI:10.3970/cmes.2014.098.069

Abstract Mechanical properties of proteins play an important role in their biological function. For example, microtubules carry large loads to transport organelles inside the cell, and virus shells undergo changes in shape and mechanical properties during maturation which affect their infectivity. Various theoretical models including continuum elasticity have been applied to study these structural properties, and a significant success has been achieved. But, the previous frameworks lack a connection between the atomic and continuum descriptions. Here this is accomplished through the development of a meshfree framework based on reproducing kernel shape functions for the large deformation… More >

Chu Wang, Lucy T. Zhang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.1, pp. 41-67, 2014, DOI:10.3970/cmes.2014.098.041

Abstract Bloodstain pattern analysis (BPA) in forensic science is an important tool to solve crime scenes. The complex dynamic behavior of blood drops poses great challenges for accurate fluid dynamic simulations. In this paper, we specifically focus on simulations of blood drop spreading and impact, which may involve contact line hysteresis and spattering of drops as they interact with solid surfaces. Here, we set up a numerical framework that combines (1) the connectivity-free front tracking (CFFT) method for modeling multiphase (air and liquid) flows and (2) a dynamic contact line model for modeling fluid-solid contact line.… More >

R.A. Regueiro^1,2, B. Zhang², S.L. Wozniak³

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.1, pp. 1-39, 2014, DOI:10.3970/cmes.2014.098.001

Abstract The paper presents three-dimensional, large deformation, coupled finite element analysis (FEA) of dynamic loading on soft biological tissues treated as biphasic (solid-fluid) porous media. An overview is presented of the biphasic solidfluid mixture theory at finite strain, including inertia terms. The solid skeleton is modeled as an isotropic, compressible, hyperelastic material. FEA simulations include: (1) compressive uniaxial strain loading on a column of lung parenchyma with either pore air or water fluid, (2) out-of-plane pressure loading on a thin slab of lung parenchyma with either pore air or water fluid, and (3) pressure loading on More >

K.P. Baxevanakis¹, A.E. Giannakopoulos²

CMES-Computer Modeling in Engineering & Sciences, Vol.97, No.6, pp. 535-544, 2014, DOI:10.3970/cmes.2014.097.535

Abstract This article has no abstract. More >

Tao Zhang^1,2, Yiqian He³, Leiting Dong⁴, Shu Li¹, Abdullah Alotaibi⁵, Satya N. Atluri^2,5

CMES-Computer Modeling in Engineering & Sciences, Vol.97, No.6, pp. 509-533, 2014, DOI:10.3970/cmes.2014.097.509

Abstract In this article, the Meshless Local Petrov-Galerkin (MLPG) Mixed Collocation Method is developed to solve the Cauchy inverse problems of Steady- State Heat Transfer In the MLPG mixed collocation method, the mixed scheme is applied to independently interpolate temperature as well as heat flux using the same meshless basis functions The balance and compatibility equations are satisfied at each node in a strong sense using the collocation method. The boundary conditions are also enforced using the collocation method, allowing temperature and heat flux to be over-specified at the same portion of the boundary. For the… More >

Xiaolin Li¹

CMES-Computer Modeling in Engineering & Sciences, Vol.97, No.6, pp. 483-507, 2014, DOI:10.3970/cmes.2014.097.483

Abstract Combining moving least square (MLS) approximations and boundary integral equations, a symmetric and boundary-only meshless method, the Galerkin boundary node method (GBNM), is developed in this paper for two- and threedimensional elasticity problems with mixed boundary conditions. Unlike other MLS-based meshless methods, boundary conditions in this meshless method can be applied directly and easily. In the GBNM, the stiffness matrices so obtained are symmetric. The property of symmetry is an added advantage in coupling the GBNM with the finite element method (FEM). Thus, a symmetric coupling of the GBNM and the FEM is also discussed More >

Jin Li^1,2, Hongxing Ru¹, Dehao Yu^3,4

CMES-Computer Modeling in Engineering & Sciences, Vol.97, No.6, pp. 463-482, 2014, DOI:10.3970/cmes.2014.097.463

Abstract The computation with Simpson’s rule for the supersingular integrals on circle is discussed. When the singular point coincides with some priori known point, the convergence rate of the Simpson rule is higher than the globally one which is considered as the superconvergence phenomenon. Then the error functional of density function is derived and the superconvergence phenomenon of composite Simpson rule occurs at certain local coordinate of each subinterval. Based on the error functional, a modify quadrature is presented. At last, numerical examples are provided to validate the theoretical analysis and show the efficiency of the More >