Pradeep M Kamath¹, C Balaji ², S P Venkateshan¹

FDMP-Fluid Dynamics & Materials Processing, Vol.9, No.2, pp. 111-126, 2013, DOI:10.3970/fdmp.2013.009.111

Abstract This paper reports the results of an experimental study on the enhancement in the heat transfer from a heated aluminium plate placed in a vertical channeland filled with an aluminium metal foam. Hydrodynamic and heat transfer experiments have been conducted for different foam thicknesses. The results of the hy-drodynamic experiments show no significant variation in the pressure drop with anincrease in the foam thickness. However, an increase in the foam thickness contributes an average heat transfer enhancement of 2 to 4 times over an empty channelfor the same Reynolds number. Correlations for Nusselt number are More >

G. Geethanjali^∗, C. Sujatha^†

Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 303-317, 2013, DOI:10.3970/mcb.2013.010.303

Abstract This paper reports a study on the biomechanical response of a human hand-arm model to random vibrations of the steering wheel of a tractor. An anatomically accurate bone-only hand-arm model from TurboSquidTM was used to obtain a finite element (FE) model to understand the Hand-arm vibration syndrome (HAVS), which is a neurological and vascular disorder caused by exposure of the human hand-arm to prolonged vibrations. Modal analysis has been done to find out the first few natural frequencies and mode shapes of the system. Coupling of degrees of freedom (DOF) had to be done in… More >

R. V. Uddanwadiker^*

Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 289-302, 2013, DOI:10.3970/mcb.2013.010.289

Abstract The aim of the study is to find most optimum combination of crown material and adhesive to avoid loosening and thereby failure of restored tooth. This study describes the Thermo-Mechanical analysis of restored molar tooth crown for determination of the stress levels due to thermal and mechanical loads on restored molar tooth. The potential use of the 3-D model was demonstrated and analyzed using different materials for crown. Thermal strain, stress and deformation were measured at hot and cold conditions in ANSYS and correlated with analytical calculation and existing experimental data for model validation and More >

Annette Doyle^*, Steven R. Crosby^†, David R. Burton^*, Francis Lilley^*, Gary Johnston^*, Winder B. Perez^‡, Terri G. Kinzy^‡, Mark F. Murphy^*,†,§

Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 275-288, 2013, DOI:10.3970/mcb.2013.010.275

Abstract Many diseases including cancer are associated with a disorganised cytoskeleton. The process of characterising how cytoskeletal disorganisation affects the mechanical properties of cells offers the potential to develop new drugs and treatment regimes that may exploit mechanical weakness in cells and tissues. This work investigated the role of actin associated proteins, namely tropomyosin 1 (tpm1p) and mitochondrial distribution and morphology protein 20 (mdm20p), on the mechanical and morphological properties of yeast cells. For the first time it was shown that deletion of both the TPM1 and MDM20 genes resulted in a decrease in Young’s modulus More >

Syed A Jamal^*

Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 267-273, 2013, DOI:10.3970/mcb.2013.010.267

Abstract Human Umbilical Cord Mesenchymal Stem Cells (hUCMSCs) were subjected to in vitro osteogenic differentiation using a novel combination of signaling molecules including BMP-2 and purmorphamine. Differentiation outcomes were assessed by calcein staining and by microscopic examination of the cytoskeleton. Calcein staining showed appreciable degree of calcium mineralization in cell culture, and changes in the morphological attributes of differentiating cells were observed vis-a-vis the actin cytoskeleton. Finally, positive calcein staining, altered cytoskeletal profile, and stress fiber formation in treated cells demonstrated, for the first time, a potentially synergistic interplay between BMP-2 and the hedgehog agonist, purmorphamine. More >

WJ Richardson^∗, DD van der Voort^∗, E Wilson^†, JE Moore Jr.^∗,‡

Molecular & Cellular Biomechanics, Vol.10, No.3, pp. 245-265, 2013, DOI:10.3970/mcb.2013.010.245

Abstract Non-uniform stress and strain fields are prevalent in many tissues in vivo, and often exacerbated by disease or injury. These mechanical gradients potentially play a role in contributing to pathological conditions, presenting a need for experimental tools to allow investigation of cell behavior within non-uniformly stimulated environments. Herein, we employ two in vitro cell-stretching devices (one previously published; one newly presented) capable of subjecting cells to cyclic, non-uniform stretches upon the surface of either a circular elastomeric membrane or a cylindrical PDMS tube. After 24 hours of cyclic stretch, 10T1/2 cells on both devices showed More >

B. Mochnacki^*, Alicja Piasecka Belkhayat^†

Molecular & Cellular Biomechanics, Vol.10, No.3, pp. 233-244, 2013, DOI:10.3970/mcb.2013.010.233

Abstract Numerical analysis of heat transfer processes proceeding in a nonhomogeneous biological tissue domain is presented. In particular, the skin tissue domain subjected to an external heat source is considered. The problem is treated as an axially-symmetrical one (it results from the mathematical form of the function describing the external heat source). Thermophysical parameters of sub-domains (volumetric specific heat, thermal conductivity, perfusion coefficient etc.) are given as interval numbers. The problem discussed is solved using the interval finite difference method basing on the rules of directed interval arithmetic, this means that at the stage of FDM More >

Ewa Majchrzak^*

Molecular & Cellular Biomechanics, Vol.10, No.3, pp. 201-232, 2013, DOI:10.3970/mcb.2013.010.201

Abstract Heat transfer processes proceeding in the living organisms are described by the different mathematical models. In particular, the typical continuous model of bioheat transfer bases on the most popular Pennes equation, but the Cattaneo-Vernotte equation and the dual phase lag equation are also used. It should be pointed out that in parallel are also examined the vascular models, and then for the large blood vessels and tissue domain the energy equations are formulated separately. In the paper the different variants of the boundary element method as a tool of numerical solution of bioheat transfer problems More >

Marek Jasiński^*

Molecular & Cellular Biomechanics, Vol.10, No.3, pp. 183-199, 2013, DOI:10.3970/mcb.2013.010.183

Abstract In the paper the numerical analysis of thermal processes proceeding in the biological tissue is presented. The tissue is subjected to the external heat flux and 2D problem is taken into account. In order to determine the influence of variations of thermophysical parameters of tissue on the value of Arrhenius injury integral the direct approach of sensitivity analysis is applied. On the basis of tissue damage fraction the thermal injury formation process is analysed. At the stage of numerical realization the boundary element method is used. In the final part of the paper the example More >

Yongren Wu^∗, Sarah Cisewski^∗, Barton L. Sachs^†, Hai Yao^∗,†,‡

Molecular & Cellular Biomechanics, Vol.10, No.2, pp. 159-182, 2013, DOI:10.3970/mcb.2013.010.159

Abstract This study examines the effects of cartilage endplate (CEP) calcification and the injection of intervertebral disc (IVD) cells on the nutrition distributions inside the human IVD under physiological loading conditions using multiphasic finite element modeling. The human disc was modeled as an inhomogeneous mixture consisting of a charged elastic solid, water, ions (Na⁺ and Cl⁻), and nutrient solute(oxygen,glucose and lactate) phases. The effect of the endplate calcification was simulated by a reduction of the tissue porosity (i.e., water volume faction) from 0.60 to 0.48. The effect of cell injection was simulated by increasing the cell density… More >