X. Neil Dong^1,2, Xiaohui Zhang¹, X. Edward Guo¹

Molecular & Cellular Biomechanics, Vol.2, No.2, pp. 63-68, 2005, DOI:10.3970/mcb.2005.002.063

Abstract In human cortical bone, cement lines (or reversal lines) separate osteons from the interstitial bone tissue, which consists of remnants of primary lamellar bone or fragments of remodeled osteons. There have been experimental evidences of the cement line involvement in the failure process of bone such as fatigue and damage. However, there are almost no experimental data on interfacial properties of cement lines in human cortical bone. The objective of this study is to design and assemble a precision and computer controlled osteon pushout microtesting system, and to experimentally determine the interfacial strength of cement… More >

Quang Dang^1,1, Hans Gregersen^2,2, Birgitte Duch^2,2, Ghassan S. Kassab^1,1

Molecular & Cellular Biomechanics, Vol.2, No.2, pp. 53-62, 2005, DOI:10.3970/mcb.2005.002.053

Abstract Biliary duct obstruction is an important clinical condition that affects millions of people worldwide. We have previously shown that the common bile duct (CBD) undergoes significant growth and remodelling post obstruction. The mechanical stress-strain relation is expected to change due to growth and remodeling in response to obstruction and hence pressure-overload. The objective of the present study was to characterize the material properties of the CBD of the sham group and at 3 hours, 12 hours, 2 days, 8 days and 32 days (n=5 in each group) after obstruction. The Fung's exponential strain energy function… More >

Wei Zhang^1,2, Carly Herrera¹, Satya N. Atluri¹, Ghassan S. Kassab^2,3

Molecular & Cellular Biomechanics, Vol.2, No.1, pp. 41-52, 2005, DOI:10.3970/mcb.2005.002.041

Abstract It is well known that blood vessels shorten axially when excised. This is due to the perivascular tethering constraint by side branches and the existence of pre-stretch of blood vessels at the \textit {in situ} state. Furthermore, vessels are radially constrained to various extents by the surrounding tissues at physiological loading. Our hypothesis is that the axial pre-stretch and radial constraint by the surrounding tissue homogenizes the stress and strain distributions in the vessel wall. A finite element analysis of porcine coronary artery and rabbit thoracic aorta based on measured material properties, geometry, residual strain More >

K. Y. Volokh ^{1, 2} , Y. Lev³

Molecular & Cellular Biomechanics, Vol.2, No.1, pp. 27-40, 2005, DOI:10.3970/mcb.2005.002.027

Abstract A simple phenomenological theory of tissue growth is used in order to demonstrate that volumetric growth combined with material anisotropy can lead to accumulation of residual stresses in arteries. The theory is applied to growth of a cylindrical blood vessel with the anisotropy moduli derived from experiments. It is shown that bending resultants are developed in the ring cross-section of the artery. These resultants may cause the ring opening or closing after cutting the artery \textit {in vitro} as it is observed in experiments. It is emphasized that the mode of the arterial ring opening More >

Nan Shen^1,2, Dabajyoti Datta¹, Chris B. Schaffer^1,3,4,5, Eric Mazur^1,6

Molecular & Cellular Biomechanics, Vol.2, No.1, pp. 17-26, 2005, DOI:10.3970/mcb.2005.002.017

Abstract Analysis of cell regulation requires methods for perturbing molecular processes within living cells with spatial discrimination on the nanometer-scale. We present a technique for ablating molecular structures in living cells using low-repetition rate, low-energy femtosecond laser pulses. By tightly focusing these pulses beneath the cell membrane, we ablate cellular material inside the cell through nonlinear processes. We selectively removed sub-micrometer regions of the cytoskeleton and individual mitochondria without altering neighboring structures or compromising cell viability. This nanoscissor technique enables non-invasive manipulation of the structural machinery of living cells with several-hundred-nanometer resolution. Using this approach, we More >

Christopher A. Lemmon^1,2, Nathan J. Sniadecki³, Sami Alom Ruiz^1,3, John L. Tan, Lewis H. Romer^2,4,5, Christopher S. Chen^3,4

Molecular & Cellular Biomechanics, Vol.2, No.1, pp. 1-16, 2005, DOI:10.3970/mcb.2005.002.001

Abstract The interplay of mechanical forces between the extracellular environment and the cytoskeleton drives development, repair, and senescence in many tissues. Quantitative definition of these forces is a vital step in understanding cellular mechanosensing. Microfabricated post array detectors (mPADs) provide direct measurements of cell-generated forces during cell adhesion to extracellular matrix. A new approach to mPAD post labeling, volumetric imaging, and an analysis of post bending mechanics determined that cells apply shear forces and not point moments at the matrix interface. In addition, these forces could be accurately resolved from post deflections by using images of More >

S.C. Forth¹, A. Staroselsky²

CMES-Computer Modeling in Engineering & Sciences, Vol.9, No.3, pp. 287-298, 2005, DOI:10.3970/cmes.2005.009.287

Abstract A new hybrid surface-integral-finite-element numerical scheme has been developed to model a three-dimensional crack propagating through a thin, multi-layered coating. The finite element method was used to model the physical state of the coating, and the surface integral method was used to model the fatigue crack growth. The two formulations are coupled through the need to satisfy boundary conditions on the crack and external surface. The coupling is sufficiently weak that the surface integral mesh of the crack surface and the finite element mesh of the uncracked volume can be set up independently. Thus, when More >

Feng Zhao¹, Song-Ping Zhu², Zhi-Rong Zhang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.9, No.3, pp. 273-286, 2005, DOI:10.3970/cmes.2005.009.273

Abstract In this paper, the steady viscous flow around a ship hull with free surface is studied through solving Reynolds Averaged Navier-Stokes (RANS) equations numerically. The RANS solver is based on a cell-centered finite-volume discretization. In our study, the turbulence is modeled through an SST (Shear Stress Transport) k - ω turbulence model in conjunction with the wall function approach for the near-wall simulation. The VOF method is used for the free surface treatment. Calculations for two typical benchmark surface ship models, Wigley and DTMB 5415, are carried out first for the purpose of model validation. The… More >

Chein-Shan Liu¹

CMES-Computer Modeling in Engineering & Sciences, Vol.9, No.3, pp. 255-272, 2005, DOI:10.3970/cmes.2005.009.255

Abstract The group-preserving scheme developed by Liu (2001) for calculating the solutions of k-dimensional differential equations system adopted the Cayley transform to formulate the Lie group from its Lie algebra A ∈ so(k,1). In this paper we consider a more effective exponential mapping to derive exp(hA). In order to overcome the difficulty of numerical instabilities encountered by employing group-preserving schemes on stiff differential equations, we further combine the nonstandard finite difference method into the group-preserving schemes to obtain unconditional stable numerical methods. They provide single-step explicit time integrators for stiff differential equations. Several numerical examples are examined, some More >

B. Chandrasekhar¹

CMES-Computer Modeling in Engineering & Sciences, Vol.9, No.3, pp. 243-254, 2005, DOI:10.3970/cmes.2005.009.243

Abstract In this work, a novel numerical technique is presented to calculate the acoustic fields scattered by three dimensional rigid bodies of arbitrary shape using the method of moment's solution procedure. A new set of basis functions, namely, Node based basis functions are developed to represent the source distribution on the surface of rigid body and the same functions are used as testing functions as well. Both single layer formulation and double layer formulations are numerically solved using the same basis functions. The surface of the body is modeled by triangular patch modeling. Numerical technique presented More >