Gloria B. Kim^1,†, Qiong Wei^2,†, Virginia Aragon-Sanabria¹, Sulin Zhang², Jian Yang¹, Cheng Dong^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 15-15, 2019, DOI:10.32604/mcb.2019.07137

Abstract Most cells survive and grow by attaching and spreading on a substrate. They generate internal tension that contracts the cell body and thus exert tractions on the underlying substrate through focal adhesions. Traction force also plays a critical role in many biological processes, such as inflammation, metastasis, and angiogenesis. Thus, measuring the cell traction force provides valuable information on understanding the underlying mechanism of these biological processes. Here, a traction force microscopy (TFM) method using super thin hydrogels composed of immobilized fluorescent beads was utilized to quantify the mechanical forces generated during the transmigration of… More >

Erik B. Kistler¹, Geert W. Schmid-Schönbein^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 8-8, 2019, DOI:10.32604/mcb.2019.07256

Abstract A longstanding question in research on organ failure after physiological shock (such as trauma, burns, sepsis, surgery and medical emergencies) is the underlying mechanism for a progressive loss of cell and tissue functions. Our systematic analysis of this problem has served to identify digestive enzymes as key players [1, 2]. After synthesis and discharge from the pancreas, the digestive enzymes are usually contained inside the lumen of the small intestine where they break down food every day. Escape of the digestive enzymes out of the lumen of the intestine is kept to a minimum by… More >

Shu Q. Liu^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 5-7, 2019, DOI:10.32604/mcb.2019.06960

Abstract This article has no abstract. More >

Caili Li¹, Jing Yao², Chun Yang³, Di Xu², Liang Wang⁴, Dalin Tang^4,5,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 77-78, 2019, DOI:10.32604/mcb.2019.05745

Abstract Pulmonary valve stenosis (PVS) is one common post-operative problem in patients with tetralogy of Fallot (TOF) after repair. Congenital bicuspid pulmonary valve (BPV) is a condition of valvular stenosis, and the occurrence of congenital BPV is often associated with TOF. Compared with the biomechanical simulation model of the bicuspid aortic valve, the BPV is often neglected. In this study, we developed a dynamic biomechanical model of a simulated normal pulmonary root (PR) with tri-leaflet and a model of simulated PR with BPV in patients with repaired TOF in order to describe the effect of geometric… More >

Han Yu¹, Pedro J. del Nido², Tal Geva³, Chun Yang⁴, Zheyang Wu⁴, Rahul H. Rathod³, Xueying Huang⁵, Kristen L. Billiar⁶, Dalin Tang^1,4,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 73-74, 2019, DOI:10.32604/mcb.2019.05837

Abstract Ventricle mechanical stress and strain calculations play an important role in cardiovascular investigations. Patients with repaired tetralogy of Fallot (TOF) account for the majority of cases with late onset right ventricular (RV) failure. The current surgical approach, including pulmonary valve replacement(PVR), has yielded mixed results with some patients recover RV function after pulmonary valve insertion with or without concomitant RV remodeling surgery but some do not[Therrien, Siu and McLaughlin (2000);]. Cardiac magnetic resonance (CMR) data were collected from 6 healthy volunteers and 12 Tetralogy of Fallot (TOF) patients before PVR with consent obtained. 12 patients… More >

Shaoxiong Yang¹, Xiaobo Gong^1,*, Yingxin Qi², Zonglai Jiang²

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 9-10, 2019, DOI:10.32604/mcb.2019.05701

Abstract Blood vessels interact with their mechanical environments in a comprehensive way. Local mechanical stimuli outside the biological range play important roles in various human cardiovascular diseases. Although many mechanobiological studies of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) in vitro have been reported in mimicking cellular dysfunctions, their quantitative correlations to the in vivo vascular conditions remain unclear. In order to interpret the stress-modulated dysfunctions of vascular cells and explore the key mechanical factors in vascular diseases, it is important to investigate the mechanical environments of vessel walls in vivo under various physiological conditions. Based on… More >

Mingge Wu¹, Lei Wang¹, Yixiang Wang¹, Cheng Zhang¹, Cheng Qiu^{1, 2, *}

FDMP-Fluid Dynamics & Materials Processing, Vol.15, No.4, pp. 431-444, 2019, DOI:10.32604/fdmp.2019.08209

Abstract Water management in proton exchange membrane fuel cells (PEMFC) is a topic of great importance for the optimization of these systems. Effective proton conductivity calls for moderate moisture content in the membrane, while uneven water distribution can lead to instability of the whole flow field, thereby decreasing the performance of the fuel cell. In the present study, a simplified two-tier hybrid structure is used to investigate the impact of the dynamic behavior of liquid water on the current density of the PEMFC. Simulation results show that water droplets attached to wall sides tend to increase More >

N. Kins Burk Sunil^{1, *}, R. Ganesan², B. Sankaragomathi³

CMES-Computer Modeling in Engineering & Sciences, Vol.118, No.2, pp. 351-375, 2019, DOI:10.31614/cmes.2018.04484

Abstract Obstructive Sleep Apnea (OSA) is a respiratory syndrome that occurs due to insufficient airflow through the respiratory or respiratory arrest while sleeping and sometimes due to the reduced oxygen saturation. The aim of this paper is to analyze the respiratory signal of a person to detect the Normal Breathing Activity and the Sleep Apnea (SA) activity. In the proposed method, the time domain and frequency domain features of respiration signal obtained from the PPG device are extracted. These features are applied to the Classification and Regression Tree (CART)-Particle Swarm Optimization (PSO) classifier which classifies the More >

Donghong He¹, Hang Ma^{2, *}

CMES-Computer Modeling in Engineering & Sciences, Vol.118, No.1, pp. 15-40, 2019, DOI:10.31614/cmes.2019.04327

Abstract To deal with the problems encountered in the large scale numerical simulation of three dimensional (3D) elastic solids with fluid-filled pores, a novel computational model with the corresponding iterative solution procedure is developed, by introducing Eshelby’s idea of eigenstrain and equivalent inclusion into the boundary integral equations (BIE). Moreover, by partitioning all the fluid-filled pores in the computing domain into the near- and the far-field groups according to the distances to the current pore and constructing the local Eshelby matrix over the near-field group, the convergence of iterative procedure is guaranteed so that the problem… More >

Pengxiao Chen¹, Kai Huang^{1, 2}, Fenghe Wang¹, Weijun Xie¹, Shuo Wei¹, Deyong Yang^{1, *}

FDMP-Fluid Dynamics & Materials Processing, Vol.15, No.4, pp. 367-389, 2019, DOI:10.32604/fdmp.2019.07762

Abstract The so-called pore network model has great advantages in describing the process of heat and mass transfer in porous media. In order to construct a random two-dimensional (2D) irregular pore network model for an unconsolidated material, image processing technology was used to extract the required topological and geometric information from a 2D sample of soybean particles, and a dedicated algorithm was elaborated to merge some adjacent small pores. Based on the extracted information, a 2D pore network model including particle information was reconstructed and verified to reflect the pore structure of discrete particles. This More >