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  • Open Access

    ARTICLE

    The Effects of Pro-inflammatory Cytokines on Functional Repair of the Meniscus

    A. L. McNulty1, F. T. Moutos1, R. E. Wilusz1, J. B. Weinberg2, F. Guilak1

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 197-198, 2006, DOI:10.32604/mcb.2006.003.197

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Adult Stem Cells and Skeletal Repair and Regeneration

    C. Niyibizi1, F. Li1, X. Wang1, X. Liao1

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 149-149, 2006, DOI:10.32604/mcb.2006.003.149

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Optimizing the Mechanical Stimulus in Culture to Improve Construct Biomechanics for Tendon Repair

    V. S. Nirmalanandhan1, J. T. Shearn1, N. Juncosa-Melvin1, M. Rao1, A. Jain1, C. Gooch1, D. L. Butler1

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 131-134, 2006, DOI:10.32604/mcb.2006.003.131

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Functional Tissue Engineering to Repair Tendon & Other Musculoskeletal Tissues

    D. L. Butler1, N. Juncosa-Melvin1, G. P. Boivin1, M. Galloway2, C. Gooch1, J. T. Shearn1, V. S. Nirmalanandhan1, S. A. Hunter1, K. Chokalingam1, C. Frede3, J. Florer3, R. Wenstrup3

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 127-130, 2006, DOI:10.32604/mcb.2006.003.127

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Linear Buckling Analysis of Shear Deformable Shallow Shells by the Boundary Domain Element Method

    P.M. Baiz1, M.H. Aliabadi1

    CMES-Computer Modeling in Engineering & Sciences, Vol.13, No.1, pp. 19-34, 2006, DOI:10.3970/cmes.2006.013.019

    Abstract In this paper the linear buckling problem of elastic shallow shells by a shear deformable shell theory is presented. The boundary domain integral equations are obtained by coupling two dimensional plane stress elasticity with boundary element formulation of Reissner plate bending. The buckling problem is formulated as a standard eigenvalue problem, in order to obtain directly critical loads and buckling modes as part of the solution. The boundary is discretised into quadratic isoparametric elements while in the domain quadratic quadrilateral cells are used. Several examples of cylindrical shallow shells (curved plates) with different dimensions and More >

  • Open Access

    ARTICLE

    Multi–Disciplinary Optimization for the Conceptual Design of Innovative Aircraft Configurations

    Luigi Morino1, Giovanni Bernardini1, Franco Mastroddi2

    CMES-Computer Modeling in Engineering & Sciences, Vol.13, No.1, pp. 1-18, 2006, DOI:10.3970/cmes.2006.013.001

    Abstract The paper presents an overview of recent work by the authors and their collaborators on multi--disciplinary optimization for conceptual design, based on the integrated modeling of structures, aerodynamics, and aeroelasticity. The motivation for the work is the design of innovative aircraft configurations, and is therefore first--principles based, since in this case the designer cannot rely upon past experience. The algorithms used and the philosophy behind the choices are discussed. More >

  • Open Access

    ARTICLE

    Modulation of the Self-assembled Structure of Biomolecules: Coarse Grained Molecular Dynamics Simulation

    Baohua Ji*, Yonggang Huang

    Molecular & Cellular Biomechanics, Vol.3, No.3, pp. 109-120, 2006, DOI:10.3970/mcb.2006.003.109

    Abstract The mechanisms governing the self-assembled structure of biomolecules (single chain and bundle of chains) are studied with an AB copolymer model via the coarse grained molecular dynamics simulations. Non-local hydrophobic interaction is found to play a critical role in the pattern formation of the assembled structure of polymer chains. We show that the polymer structure could be controlled by adjusting the balance between local (short range) and non-local (long range) hydrophobic interaction which are influenced by various factors such as the sequences, chain length, stiffness, confinement, and the topology of polymers. In addition, the competition More >

  • Open Access

    ARTICLE

    A Mathematical Model of Cell Reorientation in Response to Substrate Stretching

    Konstantinos A. Lazopoulos1, Dimitrije Stamenović2

    Molecular & Cellular Biomechanics, Vol.3, No.1, pp. 43-48, 2006, DOI:10.3970/mcb.2006.003.043

    Abstract It is well documented that in response to substrate stretching adhering cells alter their orientation. Generally, the cells reorient away from the direction of the maximum substrate strain, depending upon the magnitude of the substrate strain and the state of cell contractility. Theoretical models from the literature can describe only some aspects of this phenomenon. In the present study, we developed a more comprehensive mathematical model of cell reorientation than the current models. Using the framework of theory of non-linear elasticity, we found that the problem of cell reorientation was a stability problem, with the More >

  • Open Access

    REVIEW

    Regulation of Vascular Smooth Muscle Cells and Mesenchymal Stem Cells by Mechanical Strain

    Kyle Kurpinski1,2,3, Jennifer Park1,2,3, Rahul G. Thakar1,2,3, Song Li1,2

    Molecular & Cellular Biomechanics, Vol.3, No.1, pp. 21-34, 2006, DOI:10.3970/mcb.2006.003.021

    Abstract Vascular smooth muscle cells (SMCs) populate in the media of the blood vessel, and play an important role in the control of vasoactivity and the remodeling of the vessel wall. Blood vessels are constantly subjected to hemodynamic stresses, and the pulsatile nature of the blood flow results in a cyclic mechanical strain in the vessel walls. Accumulating evidence in the past two decades indicates that mechanical strain regulates vascular SMC phenotype, function and matrix remodeling. Bone marrow mesenchymal stem cell (MSC) is a potential cell source for vascular regeneration therapy, and may be used to More >

  • Open Access

    ARTICLE

    A Fast Space-Time BEM Method for 3D Elastodynamics

    J. X. Zhou1, T. Koziara1, T. G. Davies1

    CMES-Computer Modeling in Engineering & Sciences, Vol.16, No.2, pp. 131-140, 2006, DOI:10.3970/cmes.2006.016.131

    Abstract The classical BEM approach for elastodynamics can produce poor results when high gradients are generated by impulses. High gradient areas evolve over time and their locations are unknown a priori, so they usually can not be captured by uniform meshes. In this paper, we propose a novel method which interpolates both spatial and temporal domains. A direct space-time discretization scheme is used to capture the wave fronts accurately and to forestall generation of spurious oscillations there. Some numerical examples are given to demonstrate the power and scope of the method. More >

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