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  • Open Access

    ARTICLE

    Silencing of Armadillo Repeat-Containing Protein 8 (ARMc8) Inhibits TGF-β-Induced EMT in Bladder Carcinoma UMUC3 Cells

    Xuan Liang*, Qun-Li Men, Yong-wei Li, He-Cheng Li§, Tie Chong§, Zhao-lun Li§

    Oncology Research, Vol.25, No.1, pp. 99-105, 2017, DOI:10.3727/096504016X14719078133609

    Abstract Armadillo repeat-containing protein 8 (ARMc8) is a key factor in regulating cell migration, proliferation, tissue maintenance, and tumorigenesis. However, its role in bladder cancer remains unknown. Thus, in this study we sought to investigate the effect of ARMc8 on the epithelial-to-mesenchymal transition (EMT) progress in bladder cancer cells induced by transforming growth factor-b1 (TGF-β1). Our results found that ARMc8 was highly expressed in bladder cancer cell lines. ARMc8 silencing inhibited the TGF-β1-induced migration and invasion and suppressed the EMT progress in bladder cancer cells. Furthermore, ARMc8 silencing inhibited the TGF-β1-induced expression of β-catenin, cyclin D1, More >

  • Open Access

    ARTICLE

    EXPERIMENTAL STUDY ON WATER CURTAIN FIGHTING FIRE BASED ON INFRARED TECHNIQUE

    Hui Zhong, Guohua Chen* , Saihua Jiang

    Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-5, 2017, DOI:10.5098/hmt.8.17

    Abstract Infrared radiation is a type of electromagnetic radiation and invisible to human eyes. It is used widely in industrial, scientific, and medical applications. Pool fire is an emergent accident, which emits intense thermal radiation. In order to quantify the performance of water curtain fighting fire, a testing platform is built and experimental studies are carried out. An infrared imager is used to acquire real-time experimental data and respond to the variations of flame in time and space dimensions. Experimental principles and operating procedures are described in detail. The transmissivity is used to quantify the performance More >

  • Open Access

    ARTICLE

    MODELING OF FREE CONVECTION HEAT TRANSFER UTILIZING NANOFLUID INSIDE A WAVY ENCLOSURE WITH A PAIR OF HOT AND COLD CYLINDERS

    Zoubair Boulahia* , Abderrahim Wakif, Rachid Sehaqui

    Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-10, 2017, DOI:10.5098/hmt.8.14

    Abstract In the present work, natural convection heat transfer of Cu-water nanofluid inside a wavy wall enclosure is investigated numerically by using the finite volume discretization method. The study examines the effect of the nanoparticle volume fraction, the Rayleigh number, the wave amplitude, and the undulations number on the heat transfer rate. The results show that the heat transfer rate inside the wavy enclosure enhances by decreasing the wavy surface amplitude and increasing undulations number. It is also found that by increasing the volume fraction of nanoparticles and Rayleigh number, the heat transfer rate increases. More >

  • Open Access

    ARTICLE

    NUMERICAL ANALYSIS OF NOX PRODUCTION UNDER THE AIR STAGED COMBUSTION

    Xiangcun Qia , Mo Yanga,* , Yuwen Zhangb

    Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-8, 2017, DOI:10.5098/hmt.8.3

    Abstract The formation of thermal NO and fuel type NO emission under the air staged combustion in a tower pulverized coal fired boiler that burners are arranged in the front and the rear wall are investigated in this paper. Effects of the distribution of oxygen in the main combustion zone on NOX are then analyze qualitatively. The results show that when the SOFA ratio is 34.98%, NOX yield is at the minimum; thermal NO is not only related to temperature, but also by the influence of oxygen distribution. When oxygen is more and the temperature is high,… More >

  • Open Access

    ARTICLE

    Development of quality metrics for ambulatory pediatric cardiology: Chest pain

    Jimmy C. Lu1, Manish Bansal2, Sarina K. Behera3, Jeffrey R. Boris4, Brian Cardis5, John S. Hokanson6, Bahram Kakavand7, Roy Jedeikin8

    Congenital Heart Disease, Vol.12, No.6, pp. 751-755, 2017, DOI:10.1111/chd.12509

    Abstract Objective: As part of the American College of Cardiology Adult Congenital and Pediatric Cardiology Section effort to develop quality metrics (QMs) for ambulatory pediatric practice, the chest pain subcommittee aimed to develop QMs for evaluation of chest pain.
    Design: A group of 8 pediatric cardiologists formulated candidate QMs in the areas of history, physical examination, and testing. Consensus candidate QMs were submitted to an expert panel for scoring by the RAND-UCLA modified Delphi process. Recommended QMs were then available for open comments from all members.
    Patients: These QMs are intended for use in patients 5–18 years old, referred… More >

  • Open Access

    EDITORIAL

    From the Chair of the AAP Section on Cardiology & Cardiac Surgery

    Christopher Snyder

    Congenital Heart Disease, Vol.12, No.5, pp. 692-692, 2017, DOI:10.1111/chd.12542

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Long-term outcomes after aortic coarctation repair in Maltese patients: A population-based study

    Maryanne Caruana1, Victor Grech2

    Congenital Heart Disease, Vol.12, No.5, pp. 588-595, 2017, DOI:10.1111/chd.12488

    Abstract Objectives: To investigate survival and freedom from reintervention after aortic coarctation repair in Maltese patients and to compare cardiovascular mortality in coarctation repair survivors with that in the general population.
    Design: All 72 aortic coarctation patients with any type of repair, born by end-1997 and logged in the local database were included. Trends in timing and type of repair were determined by comparing patients born before and after 1985. Kaplan-Meier analyses of survival and reintervention-free survival were performed on the 59 repair survivors with complete follow-up data (mean follow-up 26.13 ± 9.62 (range 1.05–44.55 years). Cardiovascular mortality… More >

  • Open Access

    ARTICLE

    Hemodynamic, biological, and right ventricular functional changes following intraatrial shunt repair in patients with flow-induced pulmonary hypertension

    Chih-Hsin Hsu1,2, Jun-Neng Roan1,3, Jieh-Neng Wang4, Chien-Chi Huang5, Chao-Jung Shih3, Jyh-Hong Chen2,6, Jing-Ming Wu4, Chen-Fuh Lam7,8

    Congenital Heart Disease, Vol.12, No.4, pp. 533-539, 2017, DOI:10.1111/chd.12479

    Abstract Objectives: Atrial septal defects may result in pulmonary hypertension and right heart remodeling. We analyzed improvements in patients with flow-induced pulmonary hypertension and the activation of endothelial progenitor cells after flow reduction.
    Design: This prospective cohort study included 37 patients who were admitted for an occluder implantation. Blood samples were collected before and after the procedure. We determined the number of endothelial progenitor cells in outgrowth colonies and serum Hsp27 concentrations. Daily performance and cardiothoracic ratio were reevaluated later.
    Results: Closure of the defect significantly reduced the pulmonary pressure and B-type natriuretic peptide levels. The cardiothoracic ratio and… More >

  • Open Access

    ARTICLE

    Impaired atrioventricular transport in patients with transposition of the great arteries palliated by atrial switch and preserved systolic right ventricular function: A magnetic resonance imaging study

    Magalie Ladouceur1,2,3, Nadjia Kachenoura4, Gilles Soulat1,3, Emilie Bollache4, Alban Redheuil4, Michel Azizi3, Christophe Delclaux3, Gilles Chatellier3, Pierre Boutouyrie1,3, Laurence Iserin3, Damien Bonnet2,3, Elie Mousseaux1,3

    Congenital Heart Disease, Vol.12, No.4, pp. 458-466, 2017, DOI:10.1111/chd.12472

    Abstract Objectives: We aimed (1) determine if systemic right ventricle filling parameters influence systemic right ventricle stroke volume in adult patients with D-transposition of the great arteries (D-TGA) palliated by atrial switch, using cardiac magnetic resonance imaging and echocardiography, and (2) to study relationship of these diastolic parameters with exercise performance and BNP, in patients with preserved systolic systemic right ventricle function.
    Design: Single-center, cross-sectional, prospective study.
    Setting: In patients with D-TGA palliated by atrial switch, diastolic dysfunction of the systemic right ventricle may precede systolic dysfunction.
    Methods: Forty-five patients with D-TGA and atrial switch and 45 age and sex-matched… More >

  • Open Access

    ARTICLE

    Forced vital capacity predicts morbidity and mortality in adults with repaired tetralogy of Fallot

    Katie E. Cohen1, Matthew W. Buelow1, Jennifer Dixon1, Ruta Brazauskas2, Scott B. Cohen3, Michael G. Earing1,3, Salil Ginde1

    Congenital Heart Disease, Vol.12, No.4, pp. 435-440, 2017, DOI:10.1111/chd.12470

    Abstract Objective: Abnormal lung function characterized by a reduced forced vital capacity (FVC) is common in adults with repaired tetralogy of Fallot (TOF) and is associated with previous thoracotomies and sternotomies. The impact of abnormal lung function on clinical outcomes in adult patients with repaired TOF is unclear. The aim of this study was to determine the impact of abnormal lung function on the outcome of hospitalization and death in adults with repaired TOF when analyzed with other traditional cardiac risk factors.
    Design: Retrospective study of adults with repaired TOF, who underwent spirometry between 2000 and 2014. FVC… More >

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