Sarah A. Scuderi^*, Marika Lanza^*, Giovanna Casili^*, Francesca Esposito^†, Cristina Colarossi^‡, Dario Giuffrida^‡, Paterniti Irene^*, Salvatore Cuzzocrea^*,* Emanuela Esposito^*, Michela Campolo^*

Oncology Research, Vol.28, No.7-8, pp. 779-790, 2020, DOI:10.3727/096504021X16161478258040

Abstract Glioma are common malignant brain tumors, among which glioblastoma multiforme (GBM) has the worst prognosis. Different studies of GBM revealed that targeting nuclear factor B (NF- B) induced an attenuation tumor proliferation and prolonged cell survival. TBK1 {TANK [TRAF (TNF (tumor-necrosis-factor) receptorassociated factor)-associated NF- B activator]-binding kinase 1} is a serine/threonine protein kinase, and it is a member of the I B kinase (IKK) family involved in NF- B pathway activation. The aim of this study was to investigate the potential effect of BX795, an inhibitor of TBK1, in an in vitro and ex vivo… More >

Ching-Wen Huang^*, Cheng-Jen Ma^*†, Wei-Chih Su^*, Yi-Ting Chen^‡§, Hsiang-Lin Tsai^*¶, Yung-Sung Yeh^*#, Tsung-Kun Chang^*, Wen-Hung Hsu^**††, Fang-Jung Yu^**††, Jaw-Yuan Wang^{*¶‡‡§§¶¶##}

Oncology Research, Vol.28, No.7-8, pp. 701-714, 2020, DOI:10.3727/096504020X15986099915822

Abstract This study evaluated the survival effects of metronomic maintenance therapy with oral fluoropyrimidine in patients with stage III colorectal cancer (CRC) according to epidermal growth factor receptor (EGFR) expression. We enrolled 197 patients with stage III CRC who had undergone radical resection and FOLFOX regimen adjuvant chemotherapy. The clinicopathological features and effects of metronomic maintenance therapy with oral capecitabine (daily dose of 850 mg/m2 , twice daily, on days 1–14 every 3 weeks for 6 months) on survival according to treatment group and EGFR expression were analyzed. By conducting an in vitro cell line study… More >

Chengrong Yang¹, Rongjing Bu², Yan Kang², Yachuan Zhang², Hao Li^2,*, Tao Li², Junfeng Li²

Journal on Big Data, Vol.2, No.4, pp. 135-144, 2020, DOI:10.32604/jbd.2020.010000 - 24 December 2020

Abstract With the rise of open-source software, the social development paradigm occupies an indispensable position in the current software development process. This paper puts forward a variant of the PageRank algorithm to build the importance assessment model, which provides quantifiable importance assessment metrics for new Java projects based on Java open-source projects or components. The critical point of the model is to use crawlers to obtain relevant information about Java open-source projects in the GitHub open-source community to build a domain knowledge graph. According to the three dimensions of the Java opensource project’s project influence, project More >

Iftikhar Ahmad^1,*, Mohammed A. Alqarni², Abdulwahab Ali Almazroi³, Abdullah Tariq¹

Intelligent Automation & Soft Computing, Vol.26, No.6, pp. 1335-1344, 2020, DOI:10.32604/iasc.2020.013861 - 24 December 2020

Abstract The exponential growth of social media has been instrumental in directing the news outlets to rely on the stated platform for the dissemination of news stories. While social media has helped in the fast propagation of breaking news, it also has allowed many bad actors to exploit this medium for political and monetary purposes. With such an intention, tempting headlines, which are not aligned with the content, are being used to lure users to visit the websites that often post dodgy and unreliable information. This phenomenon is commonly known as clickbait. A number of machine… More >

Fahd N. Al-Wesabi^*

Intelligent Automation & Soft Computing, Vol.26, No.6, pp. 1345-1357, 2020, DOI:10.32604/iasc.2020.013835 - 24 December 2020

Abstract Assuring high availability is an important factor to develop component-based systems, particularly when different workloads and configurations are common. Several methods have been proposed in the literature to redeploy and replicate software components to find the best deployment architecture that guarantees high availability of component-based systems. In this paper, an extended method has been proposed to improve the availability of component-based systems by adding new CPU factors. The proposed method has been implemented by a self-developed program and using a java programming language with Eclipse KEPLER. Several simulations and experiment scenarios have been performed to… More >

Norjihan Binti Abdul Ghani¹, Muneer Ahmad¹, Zahra Mahmoud¹, Raja Majid Mehmood^2,*

Intelligent Automation & Soft Computing, Vol.26, No.6, pp. 1217-1231, 2020, DOI:10.32604/iasc.2020.011731 - 24 December 2020

Abstract Achievement of sustainable privacy preservation is mostly very challenging in a resource shared computer environment. This challenge demands a dedicated focus on the exponential growth of big data. Despite the existence of specific privacy preservation policies at the organizational level, still sustainable protection of a user’s data at various levels, i.e., data collection, utilization, reuse, and disclosure, etc. have not been implemented to its spirit. For every personal data being collected and used, organizations must ensure that they are complying with their defined obligations. We are proposing a new clustered-purpose based access control for users’… More >

WU LI¹, JIANGZHE SI², SHUAI QIU², JING LUO¹, HUIQIONG SUN¹, XIAOQING LI¹, ZHIBIN WAN¹, WEI GAO¹, HANLU ZOU¹, LEI ZHANG², XIAOHONG XIANG³, YANZHANG LI², TIESHAN TENG^2,*

BIOCELL, Vol.44, No.4, pp. 695-701, 2020, DOI:10.32604/biocell.2020.011941 - 24 December 2020

Abstract The rapid emergence of multidrug-resistant and extensively drug-resistant Tuberculosis retrieved intense interest in phage-based therapy. This old approach, which was abandoned in the west in the 1940s but is generating renewed interest, has stimulated fresh research on mycobacteriophages and their lytic efficiency against their hosts. GP30 is a novel protein of the mycobacteriophage CASbig with undiscovered function. In this study, we analyzed the role of CASbig gp30 in the host Mycobacterium smegmatis. Overexpression of gp30 in the host led to reduced growth in acidic medium and attenuated the intracellular survival rate of M. smegmatis inside the THP-1 More >

MD. ROBYUL ISLAM^1,4, TAHIA NAZNIN², DIPALI RANI GUPTA³, MD. ASHRAFUL HAQUE¹, MIRZA HASANUZZAMAN^3,*, MD. MOTIAR ROHMAN^4,*

BIOCELL, Vol.44, No.4, pp. 713-730, 2020, DOI:10.32604/biocell.2020.011812 - 24 December 2020

Abstract The current study investigated the comparative oxidative damage in two maize seedlings induced by saline, drought, and combined stress and the ameliorative role of two different doses (20 and 80 µM) of 5-aminolevulinic acid (ALA) against the above-mentioned stresses. Hydroponically grown 10-day-old maize (Zea mays, var. BARI Hybrid Maize-7 (BHM-7) and BARI Hybrid Maize-9 (BHM-9)) seedlings were exposed to 12 dS/m of saline solution, 200 mM mannitol-induced drought stress alone and their combined stress for 7 days. Result revealed that individual stresses retard the plant growth to some degrees; however, their combined stress has more detrimental… More >

TIECHENG SUN^1,#, LINGLI SONG^1,#, JING MA^2,#, HONG YU¹, SHANJIE ZHOU¹, SHUSONG WANG², LI TIAN^1,3,*

BIOCELL, Vol.44, No.4, pp. 479-485, 2020, DOI:10.32604/biocell.2020.011675 - 24 December 2020

Abstract Melatonin, as a ubiquitous indoleamine hormone, is synthesized primarily by the pineal gland. It has diverse biological effects through quite complex mechanisms. More recently, studies have focused on the mechanism of melatonin in anti-reproductive toxicity/damage. Since melatonin possesses strong antioxidant and anti-apoptotic properties, researchers have examined its potential role in protecting against male reproductive toxicity/damage, which may be induced by chemotherapy or environmental toxicants and can lead to male infertility. In this article, recent progress regarding the protective effects of melatonin on male reproductive toxicity/damage is reviewed. More >

YANJUAN LIAO^1,#, DONGLING YU^2,#, XIAOFANG QIN¹, JINMEI WU¹, HUI WEI¹, HUI LI¹, XIANGYING MA^1,*, ZAIYIN HUANG^1,*

BIOCELL, Vol.44, No.4, pp. 703-711, 2020, DOI:10.32604/biocell.2020.012047 - 24 December 2020

Abstract Despite the great potential of photosynthetic microbes in the production of renewable fuels, value-adding chemicals, and water treatment, etc., commercial utilization of them is significantly hindered by the lack of techniques to accurately monitor the thermodynamic and kinetic characteristics of the In-situ growth of microbes under controlled light illumination for optimal cultivation. Herein, we demonstrated that a newly developed highly sensitive photo-microcalorimetric system successfully captured the impacts of the light wavelength and strength on the thermodynamic and kinetic parameters of the In-situ growth of Rhodopseudomonas palustris, a representative photosynthetic microorganism. To our best knowledge, this is the More >