Fei Meng, Wei Liu

Oncology Research, Vol.23, No.1-2, pp. 7-12, 2015, DOI:10.3727/096504015X14410238486649

Abstract Cervical cancer is the second leading type of cancer in women living in less developed countries. The pathological and molecular mechanisms of cervical cancer are not comprehensively known. Though legumain has been found to be highly expressed in various types of solid tumors, its expression and biological function in cervical cancer remain unknown. In this study, we aimed to investigate legumain expression and functions in cervical cancer. We found that legumain was highly expressed in cervical cancer cells. When knocked down, legumain expression in HeLa and SiHa cells significantly reduced its migration and invasion abilities More >

Gao Liu^*, Tian Xiang^†, Quan-Feng Wu^‡, Wei-Xing Wang^*

Oncology Research, Vol.23, No.3, pp. 99-107, 2015, DOI:10.3727/096504015X14496932933575

Abstract The lncRNA H19 and its mature product miR-675 have recently been shown to be upregulated and promote the progression of gastric cancer. However, the detailed function and underlying molecular mechanism of H19/miR- 675 in the carcinogenesis of gastric cancer remains unclear. In this study, we found that H19 depended on miR- 675 to enhance the proliferation and invasion of gastric cancer AGS cells, and the expression of miR-675 was positively correlated with H19 in patients with gastric cancer. Subsequently, the tumor-suppressor runt domain transcription factor 1 (RUNX1) was confirmed to be a downstream molecule of… More >

Meng Lu¹, Yi Miao¹, Lan Qi, Mingzhu Bai, Jiarong Zhang, Youji Feng

Oncology Research, Vol.23, No.6, pp. 267-274, 2015, DOI:10.3727/096504016X14549667333963

Abstract FKBP14 belongs to the family of FK506-binding proteins (FKBPs). Altered expression of FKBPs has been reported in several malignancies. This study aimed to reveal the expression profile of FKBP14 in ovarian cancer and evaluate whether FKBP14 is a molecular target for cancer therapy. We found that the FKBP14 mRNA level was significantly higher in ovarian cancer tissues than in normal tissues. FKBP14 expression was then knocked down in two ovarian cancer cell lines, SKOV3 and HO8910 cells, by a lentiviral short hairpin RNA (shRNA) delivery system. Reduced expression of FKBP14 markedly impaired the proliferative ability More >

Zhuohuan Hu^a,*, Lulu Wang^a, Hui Wang^b, Mo Yang^a

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-8, 2015, DOI:10.5098/hmt.6.16

Abstract A numerical investigation was conducted to study the heat transfer in an aircraft cabin and the effects of air distribution under different angle and inlet velocity conditions. The Reynolds-averaged Navier–Stokes equations and the low Reynolds number turbulence model were used to simulate the airflow in the cabin. Mathematical statistics was used to process the relevant data, and statistical results revealed that different inlet angles and velocities significantly affect air temperature and flow field. The study also determined a set of optimum matching inlet vane angles and inlet velocities that result in an environment which meets More >

Biswajit De^*, Rajsekhar Panua

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-6, 2015, DOI:10.5098/hmt.6.11

Abstract An incorporated arithmetical model has been urbanized and investigated for CFD replication of a solitary cylinder, four stroke, straight inoculation, compressed ignition diesel engine of 3.5 kW for in-cylinder combustion analysis and authenticated under engine simulations at full load functioning conditions with foundation fuel diesel and 10% JME (volume basis) blend with diesel at invariable speed of 1500 rpm. For advancing the exactness of the exertion, a number of sub models, such as species transport model explaining the actual biodiesel energy content and molecular structure as soon as fuel blend is initiated, spray break-up model, More >

Junjie Chen^*, Xuhui Gao, Deguang Xu

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-13, 2015, DOI:10.5098/hmt.6.10

Abstract Effect of wall thermal conductivity on hydrogen self-ignition and hydrogen-assisted ignition of propane-air mixtures in different feeding modes from ambient cold-start conditions were investigated numerically with chemical kinetic model in Pt/γ-Al2O3 catalytic micro-combustors. For the steady and transient state, effect of wall thermal conductivity on self-ignition characteristics of lean hydrogen-air mixtures was presented, and hydrogenassisted combustion of propane-air mixtures was investigated numerically in the co-feed mode and the sequential feed mode. The computational results indicate the large thermal inertia of the micro-combustor solid structure leads to slow temperature dynamics, and transient response is dominated by… More >

A. Paberza^*, L. Stiebra, U. Cabulis

Journal of Renewable Materials, Vol.3, No.1, pp. 19-27, 2015, DOI:10.7569/JRM.2014.634138

Abstract Rigid polyurethane foams were obtained from pulp production byproducts. Three different polyols were used—tall oil polyol, lignopolyol and commercially available polyol for comparison. The obtained rigid polyurethane foams underwent photodegradation at 60°C temperature and at 0.89 W/m² intensity of UV light radiation up to 1000 h. Changes in chemical structure were observed by Fourier Transform Infrared Spectroscopy and Scanning Electron Microscopy was used to study changes in cell morphology. Spectrophotometery was used to determine yellowing of the foams. Results showed that the thickness of degraded layer for rigid polyurethane foams obtained from pulp production byproducts was More >

Henning Roedel¹, Isamar Rosa Plata¹, Michael Lepech^1,*, David Loftus²

Journal of Renewable Materials, Vol.3, No.3, pp. 183-194, 2015, DOI:10.7569/JRM.2015.634107

Abstract This article presents the sustainability assessment of a novel biocomposite material that is under investigation by NASA for use in construction in limited resource environments. The composite consists of soil particles solidified by a protein binding agent. Preliminary compressive strength data suggests the biocomposite could be used for numerous construction applications. To assess the biocomposite’s potential for use in sustainable construction, a comparative process-based life cycle assessment between biocomposite and concrete pavers was performed to analyze the life cycle primary energy and IMPACT 2002+ points of both types of pavers. Results show that the concrete More >

Yujie Zhang¹, Marc A. Dubé^1,*, Eduardo Vivaldo-Lima²

Journal of Renewable Materials, Vol.3, No.4, pp. 318-326, 2015, DOI:10.7569/JRM.2015.634115

Abstract Renewable monomers containing allylic C-H bonds in their structure are prone to degradative chain transfer in free-radical polymerization, which will dramatically decrease the polymerization rate. In order to understand this mechanism, a kinetic model incorporating a degradative chain transfer mechanism for the free-radical copolymerization of d-limonene (LIM) and n-butyl methacrylate (BMA) was developed using PREDICI. Model predictions offered insight on how degradative chain transfer reactions affect conversion, copolymer composition and molecular weight in the polymerization. Experimental data from copolymerizations at monomer feed compositions (LIM/BMA, mol/mol) of 10/90, 20/80 and 30/70 were compared to the model’s predictions. More >

M. Purushothaman¹, P. Santhana Gopala Krishnan^1,2,*, S. K. Nayak^1,2

Journal of Renewable Materials, Vol.3, No.4, pp. 292-301, 2015, DOI:10.7569/JRM.2015.634114

Abstract Four copolymers of poly(ethyl lactate acrylate-co-acrylic acid) were prepared by the solution polymerization technique by varying the comonomer content from 0.2 to 0.8 mole percent. The copolymers were characterized by FT-IR, ¹H-NMR and proton decoupled ¹³C-NMR spectroscopic techniques. The reactivity ratio of ethyl lactate acrylate (ELA) and acrylic acid (AA) was calculated using the Fineman-Ross method and the values were found to be 0.101 and 0.186, respectively, indicating the formation of an alternating copolymer. From the wide-angle X-ray diffraction studies (WAXD), the average molecular interchain spacing () was calculated from the 2θ value of amorphous halo at… More >