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  • Open Access

    ARTICLE

    Effects of Equiaxial Strain on the Differentiation of Dental Pulp Stem Cells without Using Biochemical Reagents

    F. S. Tabatabaei, M. Jazayeri, P. Ghahari, N. Haghighipour§

    Molecular & Cellular Biomechanics, Vol.11, No.3, pp. 209-220, 2014, DOI:10.3970/mcb.2014.011.209

    Abstract During orthodontic treatments, applied mechanical forces create strain and result in tooth movement through the alveolar bone. This response to mechanical strain is a fundamental biological reaction. The present study evaluated the effect of equiaxial strain within the range of orthodontic forces on the osteogenic differentiation of human dental pulp stem cells (hDPSCs). Following isolation and culture of hDPSCs, 3rd passage cells were transferred on a silicone membrane covered with collagen. Cell adhesion to the membrane was evaluated under scanning electron microscope (SEM). Cells were divided into three groups: the first group was placed in… More >

  • Open Access

    ARTICLE

    3D Echo-Based Patient-Specific Computational Left Ventricle Models to Quantify Material Properties and Stress/Strain Differences between Ventricles with and without Infarct

    Rui Fan1, Dalin Tang2,3, Jing Yao4, Chun Yang5, Di Xu4

    CMES-Computer Modeling in Engineering & Sciences, Vol.99, No.6, pp. 491-508, 2014, DOI:10.3970/cmes.2014.099.491

    Abstract Identifying ventricle material properties and its infarct area after heart attack noninvasively is of great important in clinical applications. An echo-based computational modeling approach was proposed to investigate left ventricle (LV) mechanical properties and stress conditions using patient-specific data. Echo data was acquired from one healthy volunteer (male, age: 58) and a male patient (age: 60) who had an acute inferior myocardial infarction one week before echo image acquisition. Standard echocardiograms were obtained using an ultrasound machine (E9, GE Mechanical Systems, Milwaukee, Wisconsin) with a 3V probe and data were segmented for model construction. Finite… More >

  • Open Access

    ARTICLE

    An LGDAE Method to Solve Nonlinear Cauchy Problem Without Initial Temperature

    Chein-Shan Liu 1

    CMES-Computer Modeling in Engineering & Sciences, Vol.99, No.5, pp. 371-391, 2014, DOI:10.3970/cmes.2014.099.371

    Abstract We recover an unknown initial temperature for a nonlinear heat conduction equation ut(x,t) = uxx(x,t) + H(x,t,u,ux), under the Cauchy boundary conditions specified on the left-boundary. The method in the present paper transforms the Cauchy problem into an inverse heat source problem to find F(x) in Tt(x,t) = Txx(x,t) + H + F(x). By using the GL(N,R) Lie-group differential algebraic equations (LGDAE) algorithm to integrate the numerical method of lines discretized equations from sideways heat equation, we can fast recover the initial temperature and two boundary conditions on the right-boundary. The accuracy and efficiency are confirmed by comparing the More >

  • Open Access

    ARTICLE

    A Novel Semi-Analytic Meshless Method for Solving Two- and Three-Dimensional Elliptic Equations of General Form with Variable Coefficients in Irregular Domains

    S.Yu. Reutskiy1

    CMES-Computer Modeling in Engineering & Sciences, Vol.99, No.4, pp. 327-349, 2014, DOI:10.3970/cmes.2014.099.327

    Abstract The paper presents a new meshless numerical method for solving 2D and 3D boundary value problems (BVPs) with elliptic PDEs of general form. The coefficients of the PDEs including the main operator part are spatially dependent functions. The key idea of the method is the use of the basis functions which satisfy the homogeneous boundary conditions of the problem. This allows us to seek an approximate solution in the form which satisfies the boundary conditions of the initial problem with any choice of the free parameters. As a result we separate approximation of the boundary More >

  • Open Access

    ARTICLE

    Long-term Analyses of Concrete-Filled Steel Tubular Arches Accounting for Interval Uncertainty

    Yong-Lin Pi1, Mark Andrew Bradford1

    CMES-Computer Modeling in Engineering & Sciences, Vol.99, No.3, pp. 233-253, 2014, DOI:10.3970/cmes.2014.099.233

    Abstract Creep and shrinkage of the concrete core of a concrete-filled steel tubular (CFST) arch under sustained loading are inevitable, and cause a long-term change of the equilibrium configuration of the CFST arch. As the equilibrium configuration changes continuously, the long-term radial and axial displacements of the CFST arch, stress distributions as well as the internal forces in the steel tube and the concrete core change substantially with time. Creep and shrinkage of the concrete core are related to a number of its material parameters such as its creep coefficient, aging coefficient, and shrinkage strain. The… More >

  • Open Access

    ARTICLE

    A Double Iteration Process for Solving the Nonlinear Algebraic Equations, Especially for Ill-posed Nonlinear Algebraic Equations

    Weichung Yeih1,2, I-Yao Chan1, Cheng-Yu Ku1, Chia-Ming Fan1, Pai-Chen Guan3

    CMES-Computer Modeling in Engineering & Sciences, Vol.99, No.2, pp. 123-149, 2014, DOI:10.3970/cmes.2014.099.123

    Abstract In this paper, a novel double iteration process for solving the nonlinear algebraic equations is developed. In this process, the outer iteration controls the evolution path of the unknown vector x in the selected direction u which is determined from the inner iteration process. For the inner iteration, the direction of evolution u is determined by solving a linear algebraic equation: BTBu = BTF where B is the Jacobian matrix, F is the residual vector and the superscript ''T'' denotes the matrix transpose. For an ill-posed system, this linear algebraic equation is very difficult to solve since the resulting… More >

  • Open Access

    ARTICLE

    Solution of Post-Buckling & Limit Load Problems, Without Inverting the Tangent Stiffness Matrix & Without Using Arc-Length Methods

    T.A. Elgohary1, L. Dong2, J.L. Junkins3, S.N. Atluri4

    CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.6, pp. 543-563, 2014, DOI:10.3970/cmes.2014.098.543

    Abstract In this study, the Scalar Homotopy Methods are applied to the solution of post-buckling and limit load problems of solids and structures, as exemplified by simple plane elastic frames, considering only geometrical nonlinearities. Explicitly derived tangent stiffness matrices and nodal forces of large-deformation planar beam elements, with two translational and one rotational degrees of freedom at each node, are adopted following the work of [Kondoh and Atluri (1986)]. By using the Scalar Homotopy Methods, the displacements of the equilibrium state are iteratively solved for, without inverting the Jacobian (tangent stiffness) matrix. It is well-known that,… More >

  • Open Access

    ARTICLE

    On Solving Three-dimensional Laplacian Problems in a Multiply Connected Domain Using the Multiple Scale Trefftz Method

    Cheng-Yu Ku 1,2

    CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.5, pp. 509-541, 2014, DOI:10.3970/cmes.2014.098.509

    Abstract This paper proposes the numerical solution of three-dimensional Laplacian problems in a multiply connected domain using the collocation Trefftz method with multiple source points. A numerical solution for three-dimensional Laplacian problems was approximated by superpositioning T-complete functions formulated from 36 independent functions satisfying the governing equation in the cylindrical coordinate system. To deal with complicated problems for multiply connected domain, we adopted the generalized multiple source point boundary collocation Trefftz method which allows many source points in the Trefftz formulation without using the decomposition of the problem domain. In addition, to mitigate a severely ill-conditioned More >

  • Open Access

    ARTICLE

    Interval Uncertain Optimization of Vehicle Suspension for Ride Comfort

    C. Jiang1,2, S. Yu1, H.C. Xie1, B.C. Li1

    CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.4, pp. 443-467, 2014, DOI:10.3970/cmes.2014.098.443

    Abstract Based on the interval analysis method, this paper proposes an uncertain optimization model for the ride comfort in vehicles and achieves the optimal design of vehicle ride comfort under the condition of complicated uncertainty. The spring stiffness and shock absorber damping of suspension is regarded as the design parameters, while the root mean square (RMS) of the vehicle body acceleration is treated as the design objective and the corresponding constraints are composed of suspension stiffness, natural frequency and RMS of suspension dynamic deflection. Moreover, the uncertainties of key parameters, such as sprung mass, tire stiffness, More >

  • Open Access

    ARTICLE

    Simulations of Blood Drop Spreading and Impact for Bloodstain Pattern Analysis

    Chu Wang, Lucy T. Zhang1

    CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.1, pp. 41-67, 2014, DOI:10.3970/cmes.2014.098.041

    Abstract Bloodstain pattern analysis (BPA) in forensic science is an important tool to solve crime scenes. The complex dynamic behavior of blood drops poses great challenges for accurate fluid dynamic simulations. In this paper, we specifically focus on simulations of blood drop spreading and impact, which may involve contact line hysteresis and spattering of drops as they interact with solid surfaces. Here, we set up a numerical framework that combines (1) the connectivity-free front tracking (CFFT) method for modeling multiphase (air and liquid) flows and (2) a dynamic contact line model for modeling fluid-solid contact line.… More >

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