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  • Open Access

    ARTICLE

    Strain-induced Orientation Response of Endothelial Cells: Effect of Substratum Adhesiveness and Actin-myosin Contractile Level

    Hai Ngu*, Lan Lu*, Sara J. Oswald*, Sarah Davis*, Sumona Nag*, Frank C-P Yin

    Molecular & Cellular Biomechanics, Vol.5, No.1, pp. 69-82, 2008, DOI:10.3970/mcb.2008.005.069

    Abstract Endothelial cells subjected to cyclic stretching change orientation so as to be aligned perpendicular to the direction of applied strain in a magnitude and time-dependent manner. Although this type of response is not the same as motility, it could be governed by motility-related factors such as substratum adhesiveness and actin-myosin contractile level. To examine this possibility, human aortic endothelial cells (HAEC) were uniaxially, cyclically stretched on silicone rubber membranes coated with various concentrations of fibronectin, collagen type IV and laminin to produce differing amounts of adhesiveness (measured using a radial flow detachment assay). Cells were… More >

  • Open Access

    ARTICLE

    The Coupling Method of Natural Boundary Element and Mixed Finite Element for Stationary Navier-Stokes Equation in Unbounded Domains

    Dongjie Liu1, Dehao Yu2

    CMES-Computer Modeling in Engineering & Sciences, Vol.37, No.3, pp. 305-330, 2008, DOI:10.3970/cmes.2008.037.305

    Abstract The coupling method of natural boundary element and mixed finite element is applied to analyze the stationary Navier-Stokes equation in 2-D unbounded domains. After an artificial smooth boundary is introduced, the original nonlinear problem is reduced into an equivalent problem defined in bounded computational domain. The well-posedness of the reduced problem is proved. The finite element approximation of this problem is given, and numerical example is provided to show the feasibility and efficiency of the method. More >

  • Open Access

    ARTICLE

    A Parameter Free Cost Function for Multi-Point Low Speed Airfoil Design

    G. Veble1,2,3

    CMES-Computer Modeling in Engineering & Sciences, Vol.36, No.3, pp. 243-260, 2008, DOI:10.3970/cmes.2008.036.243

    Abstract A simple cost function is proposed that depends on the inviscid pressure distribution around an airfoil and that, when minimized, results in airfoils that promote laminar flow. Additional constraints specify the design point of the airfoil. The method allows for straightforward inclusion of multiple design points. The resulting airfoils are quantitatively similar to those already successfully used in practice. More >

  • Open Access

    ARTICLE

    Probabilistic Collocation used in a Two-Step approach for \\efficient uncertainty quantification in computational fluid dynamics.

    G.J.A. Loeven1,2, H. Bijl3

    CMES-Computer Modeling in Engineering & Sciences, Vol.36, No.3, pp. 193-212, 2008, DOI:10.3970/cmes.2008.036.193

    Abstract In this paper a Two-Step approach is presented for uncertainty quantification for expensive problems with multiple uncertain parameters. Both steps are performed using the Probabilistic Collocation method. The first step consists of a sensitivity analysis to identify the most important parameters of the problem. The sensitivity derivatives are obtained using a first or second order Probabilistic Collocation approximation. For the most important parameters the probability distribution functions are propagated using the Probabilistic Collocation method using higher order approximations. The Two-Step approach is demonstrated for flow around a NACA0012 airfoil with eight uncertain parameters in the More >

  • Open Access

    ARTICLE

    Meshless Analysis of Ductile Failure

    L. Li, S. Liu, H. Wang1

    CMES-Computer Modeling in Engineering & Sciences, Vol.36, No.2, pp. 173-192, 2008, DOI:10.3970/cmes.2008.036.173

    Abstract We study ductile fracture using Reproducing Kernel Particle Interpolation and the Gurson-Tvergaard-Needleman (GTN) model. The meshless simulations are compared with the available experimental results and previous finite element simulations for crack propagation. The results agree well with experimental results, and it is confirmed that the proposed method provides a convenient and yet accurate means for simulation of ductile fracture. More >

  • Open Access

    ARTICLE

    Global/Local FEM-BEM Stress Analysis of Damaged Aircraft Structures

    A. Alaimo1, A. Milazzo2, C. Orlando3

    CMES-Computer Modeling in Engineering & Sciences, Vol.36, No.1, pp. 23-42, 2008, DOI:10.3970/cmes.2008.036.023

    Abstract In this paper a Hierarchical approach for the analysis of advanced aerospace structures is presented. The proposed Global/Local model uses two kind of numerical methods. The first step of the Hierarchical procedure is performed by the Finite Element code Patran/Nastran\texttrademark , using a coarse mesh to study the global structure, then the local region is analyzed by using a Boundary Element code based on the multidomain anisotropic technique. This code accurately predicts stress concentrations at crack tips with a reduction of the modeling efforts and of the computational time. The Global/Local interface code implemented allows More >

  • Open Access

    ARTICLE

    The Artificial Boundary Method for a Nonlinear Interface Problem on Unbounded Domain

    De-hao Yu1 ,Hong-ying Huang2

    CMES-Computer Modeling in Engineering & Sciences, Vol.35, No.3, pp. 227-252, 2008, DOI:10.3970/cmes.2008.035.227

    Abstract In this paper, we apply the artificial boundary method to solve a three-dimensional nonlinear interface problem on an unbounded domain. A spherical or ellipsoidal surface as the artificial boundary is introduced. The exact artificial boundary conditions are derived explicitly in terms of an infinite series and then the well-posedness of the coupled weak formulation in a bounded domain, which is equivalent to the original problem in the unbounded domain, is obtained. The error estimate depends on the mesh size, the term after truncating the infinite series and the location of the artificial boundary. Some numerical More >

  • Open Access

    ARTICLE

    A Highly Accurate MCTM for Inverse Cauchy Problems of Laplace Equation in Arbitrary Plane Domains

    Chein-Shan Liu1

    CMES-Computer Modeling in Engineering & Sciences, Vol.35, No.2, pp. 91-112, 2008, DOI:10.3970/cmes.2008.035.091

    Abstract We consider the inverse Cauchy problems for Laplace equation in simply and doubly connected plane domains by recoverning the unknown boundary value on an inaccessible part of a noncircular contour from overspecified data. A modified Trefftz method is used directly to solve those problems with a simple collocation technique to determine unknown coefficients, which is named a modified collocation Trefftz method (MCTM). Because the condition number is small for the MCTM, we can apply it to numerically solve the inverse Cauchy problems without needing of an extra regularization, as that used in the solutions of More >

  • Open Access

    ARTICLE

    Inverse Scatterer Reconstruction in a Halfplane Using Surficial SH Line Sources

    C. Jeong1, L.F. Kallivokas2

    CMES-Computer Modeling in Engineering & Sciences, Vol.35, No.1, pp. 49-72, 2008, DOI:10.3970/cmes.2008.035.049

    Abstract We discuss the inverse scattering problem of identifying the shape and location of a rigid scatterer fully buried in a homogeneous halfplane, when illuminated by surficial (line) wave sources generating SH waves. To this end, we consider the full-waveform response of the coupled host-obstacle system in the frequency domain, and employ the apparatus of partial-differential-equation-constrained optimization, augmented with total differentiation for tracking shape evolutions across inversion iterations, and specialized continuation schemes in lieu of formal regularization. We report numerical results that provide evidence of algorithmic robustness for detecting a variety of shapes, including elliptically- and More >

  • Open Access

    ARTICLE

    Strain Measurement in a Microstructure Using Digital Image Correlation for a Laser-Scanning Microscopic Image

    N. Shishido, T. Ikeda, N. Miyazaki

    CMES-Computer Modeling in Engineering & Sciences, Vol.35, No.1, pp. 1-20, 2008, DOI:10.3970/cmes.2008.035.001

    Abstract We propose an image correction method that will accurately measure full-field displacement in a microstructure using the digital image correlation method (DICM); the proposed method is suitable for use with laser-scanned images. Laser scanning microscopes have higher spatial resolution and deeper depth of field than optical microscopes, but errors in laser scanning position (time-dependent distortion) affect the accuracy of the DICM. The proposed image correction method involves the removal of both time-dependant and time-independent distortions. Experimental results using images of prescribed rigid-body motions demonstrate that the proposed correction method is capable of identifying and removing… More >

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