P. Jose¹, R.Kanapady², K.K.Tamma³

CMES-Computer Modeling in Engineering & Sciences, Vol.5, No.5, pp. 409-422, 2004, DOI:10.3970/cmes.2004.005.409

Abstract In this article, a novel hybrid finite element and Laplace transform formulation is presented for the computations of transient electromagnetic fields. The formulation is first based on application of Laplace transform technique for the pertinent differential equations, namely the Maxwell's equation in the non-integral form with subsequently, employing the Galerkin finite element formulations on the transformed equations to maintain the modeling versatility of complex geometries and numerical features for computational analysis. In addition, in conjunction with the above, proper scaling of the field quantities is applied to improve the condition of the effective global stiffness More >

J. S. Hesthaven¹, T. Warburton²

CMES-Computer Modeling in Engineering & Sciences, Vol.5, No.5, pp. 395-408, 2004, DOI:10.3970/cmes.2004.005.395

Abstract We discuss the formulation, validation, and parallel performance of a high-order accurate method for the time-domain solution of the three-dimensional Maxwell's equations on general unstructured grids. Attention is paid to the development of a general discontinuous element/penalty approximation to Maxwell's equations and a locally divergence free form of this. We further discuss the motivation for using a nodal Lagrangian basis for the accurate and efficient representation of solutions and operators. The performance of the scheme is illustrated by solving benchmark problems as well as large scale scattering applications. More >

O. Hassan¹, K. Morgan, J. Jones, B. Larwood, N. P. Weatherill

CMES-Computer Modeling in Engineering & Sciences, Vol.5, No.5, pp. 383-394, 2004, DOI:10.3970/cmes.2004.005.383

Abstract A numerical procedure for the simulation of 3D problems involving the scattering of electromagnetic waves is presented. As practical problems of interest in this area often involve domains of complex geometrical shape, an unstructured mesh based method is adopted. The solution algorithm employs an explicit finite element procedure for the solution of Maxwell's curl equations in the time domain using unstructured tetrahedral meshes. A PML absorbing layer is added at the artificial far field boundary that is created by the truncation of the physical domain prior to the numerical solution. The complete solution procedure is More >

V.K. Tewary², D.T. Read²

CMES-Computer Modeling in Engineering & Sciences, Vol.6, No.4, pp. 359-372, 2004, DOI:10.3970/cmes.2004.006.359

Abstract An integrated Green's function and molecular dynamics technique is developed for multiscale modeling of a nanostructure in a semi-infinite crystal lattice. The equilibrium configuration of the atoms inside and around the nanostructure is calculated by using molecular dynamics that accounts for nonlinear interatomic forces. The molecular dynamics is coupled with the lattice statics Green's function for a large crystallite containing a million or more atoms. This gives a fully atomistic description of a nanostructure in a large crystallite that includes the effect of nonlinear forces. The lattice statics Green's function is then related to the… More >

Jihan Kim¹, Yong Hyup Kim¹, Sung Won Lee²

CMES-Computer Modeling in Engineering & Sciences, Vol.6, No.3, pp. 263-276, 2004, DOI:10.3970/cmes.2004.006.263

Abstract The Koiter's asymptotic method is combined with the assumed strain solid shell element formulation for postbuckling analysis of composite and sandwich structures. The assumed strain solid shell element is free of locking and the small angle assumption, and it allows multiple plies through the element thickness. While laminated composite structures are modeled with single element through the thickness, sandwich structures are modeled with three elements stacked through the thickness to model the face sheets and the core independently. The Koiter's method is used to trace initial postbuckling path. Subsequently, the Koiter's method is switched to More >

E. Ferretti¹

CMES-Computer Modeling in Engineering & Sciences, Vol.6, No.3, pp. 227-244, 2004, DOI:10.3970/cmes.2004.006.227

Abstract Defining the crack path in brittle and non-brittle crack is not easy, due to several unknowns. If the direction of crack propagation can be computed by means of one of the existing criteria, it is not known whether this direction will remain constant during crack propagation. A crack initiation leads to an enhanced stress field at crack tip. During propagation, the enhanced tip stress field propagates into the solid, locally interacting with the pre-existing stress field. This interaction can lead to modifications of the propagation direction, depending on the domain and crack geometry. Moreover, trajectory… More >

T. Tsangaris¹, Y.–S. Smyrlis^{1, 2}, A. Karageorghis^{1, 2}

CMC-Computers, Materials & Continua, Vol.1, No.3, pp. 245-258, 2004, DOI:10.3970/cmc.2004.001.245

Abstract The Method of Fundamental Solutions (MFS) is a boundary-type method for the solution of certain elliptic boundary value problems. In this work, we develop an efficient matrix decomposition MFS algorithm for the solution of biharmonic problems in annular domains. The circulant structure of the matrices involved in the MFS discretization is exploited by using Fast Fourier Transforms. The algorithm is tested numerically on several examples. More >

Séverine Froget¹, Emmanuelle Barthelemy², François Guillot¹, Christophe Soler¹, Marie-Claude Coudert², Marc Benbunan², Christine Dosquet^2,3

European Cytokine Network, Vol.14, No.1, pp. 60-64, 2003

Abstract Cell and tissue therapy applications in humans are being used increasingly, particularly for tissue repair. Several reconstructed skin models have been proposed. Wound healing involves overlapping steps of inflammation, cell migration and proliferation, neovascularisation, extracellular matrix production and remo-delling. This is regulated by numerous cytokines and other soluble mediators. We have prepared dermal substitutes (DS) consisting of a collagen-GAG, three-dimensional matrix colonized by human dermal fibroblasts (HDF), isolated by skin explant or enzymatic digestion of the skin for potential therapeutic use in humans. To test the functionality of these DS, we measured (ELISA) the stimulatory… More >

John K. A. Tetteh¹, Mark M. Addae¹, Naruhiko Ishiwada², Sena M. Yempewu¹, Shinya Yamaguchi¹, David Ofori-Adjei¹, Hitoshi Kamiya⁴, Yoshihiro Komada³, Bartholomew D. Akanmori^1,*

European Cytokine Network, Vol.14, No.2, pp. 109-113, 2003

Abstract To understand the pathogenesis of vaccine-modified measles (VMM), we measured plasma levels of IFN-γ and IL-2 (Th1 cytokines), IL-4 and IL-10 (Th2 cytokines), IL-12, TNF-α and TGF-β1 in children with uncomplicated measles, who had anti-measles IgG antibodies and with a history of immunization on admission (day 0), day 14 and day 60. We compared these to levels in healthy, age-matched, immunized children. Plasma levels of IFN-γ, IL-2 and IL-12 were significantly higher in VMM patients on day 0 compared to healthy controls (p = 0.023; p = 0.018; p = 0.001) respectively. In contrast, plasma… More >

Anita W. Rijneveld^1,2,*, Sandrine Florquin³, Peter Speelman^2,4, Carl K. Edwards⁵, Charles A. Dinarello⁶, Tom van der Poll^2,4

European Cytokine Network, Vol.14, No.4, pp. 242-245, 2003

Abstract The inhibition of the biological activity of IL-1 by recombinant human IL-1 receptor antagonist (IL-1ra) has been investigated in several, controlled clinical trials. Encouraging results have been reported, in particular in patients with rheumatoid arthritis. In the present study, we investigated the influence of treatment of wild type mice with IL-1ra, which resulted in an incomplete and transient inhibition of IL-1 activity. Treatment with recombinant human IL-1ra resulted in an enhanced bacterial outgrowth in the lungs of BALB/c and C57BL/6 mice early after induction of pneumococcal pneumonia, without influencing survival or the pulmonary inflammatory response. More >