Daniel P. Petrylak

Canadian Journal of Urology, Vol.21, Suppl.2, pp. 77-83, 2014

Abstract instruction: Introduction: Chemotherapy, once thought to be toxic and ineffective in men with castration-resistant prostate cancer (CRPC), has a significant impact on survival and quality-of-life in these patients. This article summarizes recent studies performed with two Food and Drug Administration (FDA) approved agents which have improved survival in men with CRPC, docetaxel and cabazitaxel.
instruction: Materials and methods: The literature on cytotoxic chemotherapy for castration-resistant prostate cancer was reviewed. The individual efficacy, mechanisms of chemotherapeutic action, and appropriate disease states of administration were identified. Recent clinical trial results of chemotherapy combined with targeted agents was also reviewed.
instruction:… More >

Leonard G. Gomella¹, Daniel P. Petrylak², Bobby Shayegan³

Canadian Journal of Urology, Vol.21, Suppl.2, pp. 1-6, 2014

Abstract instruction: Introduction: Newer approaches to the management of advanced prostate cancer have rapidly evolved. While basic androgen deprivation remains as the first line in newly diagnosed hormone naïve metastatic prostate cancer, the agents used and strategies followed have undergone significant changes. Numerous new agents such as sipuleucel-T, abiraterone, enzalutamide, cabazitaxel and radium-223 have all been approved since 2010 to treat metastatic castration-resistant prostate cancer (CRPC). New imaging techniques to detect advanced disease such as F-18 PET, 11C-choline PET and other modalities are becoming available. The concepts of "bone health" and the management of side effects related… More >

Guido Giusti¹, Silvia Proietti¹, Lorenzo G. Luciani², Roberto Peschechera¹, Antonella Giannantoni³, Gianluigi Taverna¹, Giuseppe Sortino^1,4, Pierpaolo Graziotti¹

Canadian Journal of Urology, Vol.21, No.2, pp. 7207-7212, 2014

Abstract Introduction: Major kidney stones have traditionally been treated with percutaneous nephrolithotomy. However, retrograde intrarenal surgery (RIRS), which until a few years ago was considered inappropriate for this purpose, is becoming a viable, attractive alternative. The aim of the current study was to assess the efficacy and safety of RIRS combined with holmium laser lithotripsy for the treatment of stones >2 cm in diameter in a large series of patients, reporting complications according to the Clavien-Dindo classification.
Materials and methods: By retrospective analysis, we identified a total of 162 patients who were affected by stones greater than… More >

Qian J^1,2, Z Wang¹, Z Liu¹, W Kuang^1,2, CA Busso³

Phyton-International Journal of Experimental Botany, Vol.83, pp. 407-414, 2014, DOI:10.32604/phyton.2014.83.407

Abstract Understanding the changes in the total bud bank, and its contribution to community regeneration, in response to grassland enclosure to livestock grazing, is crucial for grassland management. Despite its importance, the contribution of the total bud bank and that of different bud types to community regeneration as a whole have been rarely explored. The vegetative offspring recruited from different bud types was investigated in grasslands having different enclosure durations to livestock grazing on a typical steppe of Inner Mongolia, China. Total vegetative offspring density was significantly higher (p<0.05) under continuous grazing than in fenced grasslands,… More >

Usama K Abdel-Hameed

Phyton-International Journal of Experimental Botany, Vol.83, pp. 363-367, 2014, DOI:10.32604/phyton.2014.83.363

Abstract In Egypt there are two different species that are commercially marketed under the same trade name of Neem: one is Azadirachta indica A. Juss., and the other is Melia azedarach L. In this paper, leaf morphological characters (e.g., lamina architecture, stomatography, petiole and blade micromorphology) of both taxa were described and illustrated to aid in the identification and differentiation between the two misidentified taxa. The obtained results concluded that leaf morpho-anatomical characters will not only provide criteria for their correct taxonomic authentication, but would also serve as future standard data for the quality assessment of the pharmaceutical More >

Lira-Saldivar RH¹, A Hernández¹, LA Valdez², A Cárdenas¹, L Ibarra¹, M Hernández³, N Ruiz⁴

Phyton-International Journal of Experimental Botany, Vol.83, pp. 133-138, 2014, DOI:10.32604/phyton.2014.83.133

Abstract The response of cherry tomato to biofertilization with beneficial microorganisms was evaluated under shadehouse conditions. Seeds were inoculated and/or co-inoculated with Azospirillum brasilense (Az) and/or Glomus intraradices (Gi). Thereafter, seedlings of six treatments received two applications of a suspension containing Az + Gi at 15 and 30 days after the transplant, and were compared against a non-inoculated treatment which only received conventional inorganic fertilization. Seed co-inoculation with A. brasilense and G. intraradices plus two applications of Az + Gi at 15 and 30 days after transplant increased on average 6% plant height, 11% leaf area, 10.5% dry biomass and More >

VIVIANE DAL-SOUTO FRESCURA¹, ANDRIELLE WOUTERS KUHN¹, HAYWOOD DAIL LAUGHINGHOUSE IV², JUÇARA TEREZINHA PARANHOS¹, SOLANGE BOSIO TEDESCO¹

BIOCELL, Vol.37, No.2, pp. 23-28, 2013, DOI:10.32604/biocell.2013.37.023

Abstract Species of the genus Psychotria are used for multiple purposes in Brazilian folk medicine, either as water infusions, baths or poultices. This study was aimed to evaluate the genotoxic and antiproliferative effects of infusions of Psychotria brachypoda and P. birotula on the Allium cepa test. Exposure to distilled water was used as a negative control, while exposure to glyphosate was used as a positive control. The interaction of extracts (as a post-treatment) with the effects of glyphosate was also studied. Results showed that glyphosate and the extracts of both P. brachypoda and P. birotula reduced the mitotic index as compared… More >

Peter G^1,2, FA Funk³, A Loydi⁴, AI Casalini⁵, CV Leder⁴

Phyton-International Journal of Experimental Botany, Vol.81, pp. 233-237, 2012, DOI:10.32604/phyton.2012.81.233

Abstract In the western Monte Phytogeographical Province of Rio Negro, vegetation is a shrubby-grassland steppe, where plants are interspersed within a bare soil matrix forming “phytogenic islands”. The objective of this study was to evaluate the specific composition and cover of the study ecological system under different grazing pressures. We selected areas with high, moderate and low grazing intensity at three sites. In each area we established five linear transects, where basal cover and all intercepted species were registered. Sites were arranged through a Principal Component Analysis using the Infostat software. We analyzed similarity between sites, More >

Prashant Malhotra, Bruce F. Farber

Canadian Journal of Urology, Vol.18, No.3, pp. 5671-5675, 2011

Abstract Bacillus Calmette Guerin (BCG) immunotherapy is widely used for treatment of superfi cial bladder transitional cell carcinoma. Infectious complications while rare can be serious and severe disseminated infections as well as sepsis has been reported. There are no standard guidelines to direct therapy of these complications. Isoniazid is a commonly and widely used component of the various treatment regimens. Various strains of BCG are used for treatment of bladder cancer as well as vaccinations. These strains have evolved because of repeated subcultures in various laboratories in the world and have been shown to exhibit phenotypic… More >

Daniel Canter, Alexander Kutikov, Konstantin Golovine, Petr Makhov, Jay Simhan, Robert G. Uzzo, Vladimir M. Kolenko

Canadian Journal of Urology, Vol.18, No.4, pp. 5819-5825, 2011

Abstract Objectives: We examined the in vitro cellular effects of the multi-targeted receptor tyrosine kinase inhibitors (TKIs) sunitinib and pazopanib on a series of human renal cell carcinoma (RCC) cell lines.
Methods: The human RCC cell lines 769-P, 786-O, HRC-24, HRC-31, HRC-45, HRC-78, SK-26B, and SK-45 were treated with varying concentrations of sunitinib and pazopanib. Cellular proliferation and cell death were assessed using the CellTiter-Blue Cell Viability Assay and the TUNEL assay, respectively. Effective doses (ED) for inhibition of cellular proliferation or induction of apoptosis were calculated for both sunitinib and pazopanib in each RCC cell line.
Results: Both… More >