VIVIANE DAL-SOUTO FRESCURA¹, ANDRIELLE WOUTERS KUHN¹, HAYWOOD DAIL LAUGHINGHOUSE IV², JUÇARA TEREZINHA PARANHOS¹, SOLANGE BOSIO TEDESCO¹

BIOCELL, Vol.37, No.2, pp. 23-28, 2013, DOI:10.32604/biocell.2013.37.023

Abstract Species of the genus Psychotria are used for multiple purposes in Brazilian folk medicine, either as water infusions, baths or poultices. This study was aimed to evaluate the genotoxic and antiproliferative effects of infusions of Psychotria brachypoda and P. birotula on the Allium cepa test. Exposure to distilled water was used as a negative control, while exposure to glyphosate was used as a positive control. The interaction of extracts (as a post-treatment) with the effects of glyphosate was also studied. Results showed that glyphosate and the extracts of both P. brachypoda and P. birotula reduced the mitotic index as compared… More >

Peter G^1,2, FA Funk³, A Loydi⁴, AI Casalini⁵, CV Leder⁴

Phyton-International Journal of Experimental Botany, Vol.81, pp. 233-237, 2012, DOI:10.32604/phyton.2012.81.233

Abstract In the western Monte Phytogeographical Province of Rio Negro, vegetation is a shrubby-grassland steppe, where plants are interspersed within a bare soil matrix forming “phytogenic islands”. The objective of this study was to evaluate the specific composition and cover of the study ecological system under different grazing pressures. We selected areas with high, moderate and low grazing intensity at three sites. In each area we established five linear transects, where basal cover and all intercepted species were registered. Sites were arranged through a Principal Component Analysis using the Infostat software. We analyzed similarity between sites, More >

Prashant Malhotra, Bruce F. Farber

Canadian Journal of Urology, Vol.18, No.3, pp. 5671-5675, 2011

Abstract Bacillus Calmette Guerin (BCG) immunotherapy is widely used for treatment of superfi cial bladder transitional cell carcinoma. Infectious complications while rare can be serious and severe disseminated infections as well as sepsis has been reported. There are no standard guidelines to direct therapy of these complications. Isoniazid is a commonly and widely used component of the various treatment regimens. Various strains of BCG are used for treatment of bladder cancer as well as vaccinations. These strains have evolved because of repeated subcultures in various laboratories in the world and have been shown to exhibit phenotypic… More >

Daniel Canter, Alexander Kutikov, Konstantin Golovine, Petr Makhov, Jay Simhan, Robert G. Uzzo, Vladimir M. Kolenko

Canadian Journal of Urology, Vol.18, No.4, pp. 5819-5825, 2011

Abstract Objectives: We examined the in vitro cellular effects of the multi-targeted receptor tyrosine kinase inhibitors (TKIs) sunitinib and pazopanib on a series of human renal cell carcinoma (RCC) cell lines.
Methods: The human RCC cell lines 769-P, 786-O, HRC-24, HRC-31, HRC-45, HRC-78, SK-26B, and SK-45 were treated with varying concentrations of sunitinib and pazopanib. Cellular proliferation and cell death were assessed using the CellTiter-Blue Cell Viability Assay and the TUNEL assay, respectively. Effective doses (ED) for inhibition of cellular proliferation or induction of apoptosis were calculated for both sunitinib and pazopanib in each RCC cell line.
Results: Both… More >

Bob Djavan¹, Kathleen Nelson², Amir Kazzazi¹, Aron Bruhn¹, Helen Sadri¹, Alejandro Gomez-Pinillos³, Anna C. Ferrari³

Canadian Journal of Urology, Vol.18, No.5, pp. 5865-5874, 2011

Abstract Prostate cancer is a complex disease, and treatment selection is informed by numerous variables depending on the stage of disease. Moreover, patient expectations and the impact of treatment-related adverse events may infl uence treatment choices. Available treatment options over the course of the disease have included surgery, radiation therapy, hormonal therapy, immunotherapy, and chemotherapy. This complexity requires an understanding of a wide range of treatment options and the support of a multidisciplinary team that involves urologists, radiation oncologists, diagnostic radiologists, pathologists, and medical oncologists. Collaboration among these physicians allows for a comprehensive treatment strategy that… More >

Gokhan Koc¹, Xu Wang², Yi Luo³

Canadian Journal of Urology, Vol.18, No.6, pp. 5991-5997, 2011

Abstract Introduction: Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, responsible for approximately 90% of all kidney cancers. Prior to 2005, treatment options for patients with locally advanced and metastatic disease were limited. After the approval of sorafenib by the US Food and Drug Administration (FDA), other tyrosine kinase inhibitors (TKI) have been successively used for treating patients with advanced RCC. Pazopanib is the newest, orally bioavailable, and multi-targeted TKI, and is considered a first-line treatment option for certain patients. This review summarizes updated clinical studies, mechanism of action, and pharmacokinetics… More >

MIRIAM TERUEL^1,2, JAQUELINE D’ERCOLE¹ AND RODOLFO CATALANO²

BIOCELL, Vol.35, No.1, pp. 29-34, 2011, DOI:10.32604/biocell.2011.35.029

Abstract Benzimidazole compounds are used in both humans and animals for controlling helminth parasites. Albendazole has teratogenic effects attributed to its active metabolite albendazole sulphoxide. The aim of this work was to evaluate the effect of the latter compound when administered to pregnant CF1 mice during the preimplantation period. Females were superovulated by intraperitoneal injection of 10 IU of eCG and 10 IU of hCG (48h later) and were paired with males of proven fertility. Albendazole sulphoxide (200 mg/kg) was orally administered by gavages at day 1, 2 or 3 of pregnancy; the control group received More >

Villamil MB¹, NM Amiotti², N Peinemann³

Phyton-International Journal of Experimental Botany, Vol.80, pp. 193-201, 2011, DOI:10.32604/phyton.2011.80.193

Abstract Demand for greater cattle production at the El Caldenal area in central Argentina has resulted in overgrazing in a patchy grassland structure. Patches are clearly identified on the basis of dominant plant species resulting from their grazing history. Our primary objective was to examine the influence of individual plants at each patch on the local multivariate pattern of soil nutrients, assessing the magnitude of the association between the concentration of nutrients in the plant and its underlying soil. Canonical discriminant analysis highlighted the important role of soil organic matter, available P, and Zn content of More >

García Osuna HT, A Benavides Mendoza, L Escobedo Bocardo, JA Villarreal Quintanilla, E Cornejo Oviedo

Phyton-International Journal of Experimental Botany, Vol.80, pp. 175-179, 2011, DOI:10.32604/phyton.2011.80.175

Abstract Turbinicarpus valdezianus is a species under special protection, according to the current law NOM-059-ECOL-2010. It spreads preferably through shoot proliferation in vitro. A common problem associated with the propagation of this species by tissue culture is the hyperhydricity or excess of water accumulation in the tissues of shoots explants. The literature on this topic indicates that such response is related with oxidative stress. Because of this, the effects of inhibitors of the gibberellins [paclobutrazol (PBZ) and calcium prohexadione (PCa)] and salicylic (SA) and benzoic acids (BA) were tested to diminish the hiperhydrycity of the sprouts, which was… More >

Pérez Castañeda LM, MA Cruz Hernández, A Mendoza Herrera

Phyton-International Journal of Experimental Botany, Vol.80, pp. 27-34, 2011, DOI:10.32604/phyton.2011.80.027

Abstract Various studies have shown the symbiotic association of Azospirillum brasilense with different grasses of nutritional importance. A high variability among the isolated strains has been observed. This is consistent with the genetic diversity that Azospirillum has shown in sugarcane isolates. However, if this is also the case in maize and sorghum isolates is unknown. In addition, it has also been reported that most of the isolates come from tropical regions where water is not limiting for maize and sorghum production. We analyzed the genetic variability of Azospirillum brasilense isolates obtained from arid zones of Northeast Mexico in maize… More >