Susana N. Diniz1,2, Karen P. T. Pendeloski1, Andrey Morgun1,3, Iouri Chepelev4, Maria Gerbase-DeLima1,*, Natalia Shulzhenko1,3,*
European Cytokine Network, Vol.21, No.4, pp. 308-318, 2010, DOI:10.1684/ecn.2010.0218
Abstract The human IL-15RA gene encoding the alpha chain of the IL-15 receptor is expressed in a varietyof immune and non-immune cell types from different tissues, and generates multiple splicing events of func-tional importance. We aimed to evaluate expression of IL-15RA transcripts generated by alternative usage oftranscription start site (Var1 and Var2) and by deletion of exon 3 (Del3), exon 2 (Del2), or both (Del2,3) in dif-ferent human tissues. Since a CpG island was found near to the IL-15RA gene transcription start site, we alsoinvestigated the role of DNA methylation on the expression of IL-15RA full-length… More >