Jianhang Du^1,2,3, Liang Wang⁴

Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 249-263, 2015, DOI:10.3970/mcb.2015.012.249

Abstract Growing evidences suggest that long-term enhanced external counterpulsation (EECP) treatment can inhibit the initiation of atherosclerotic lesion by improving the hemodynamic environment in aortas. However, whether this kind procedure will intervene the progression of advanced atherosclerotic plaque remains elusive and causes great concern in its clinical application presently. In the current paper, a pilot study combining animal experiment and numerical simulation was conducted to investigate the acute mechanical stress variations during EECP intervention, and then to assess the possible chronic effects. An experimentally induced hypercholesterolemic porcine model was developed and the basic hemodynamic measurement was… More >

Tushar Kulkarni^1,2, Rashmi Uddanwadiker¹

Molecular & Cellular Biomechanics, Vol.12, No.3, pp. 147-195, 2015, DOI:10.3970/mcb.2015.012.147

Abstract Continuous growth in industrialization and lack of awareness in safety parameters the cases of amputations are growing. The search of safer, simpler and automated prosthetic arms for managing upper limbs is expected. Continuous efforts have been made to design and develop prosthetic arms ranging from simple harness actuated to automated mechanisms with various control options. However due the cost constraints, the automated prosthetic arms are still out of the reach of needy people. Recent data have shown that there is a wide scope to develop a low cost and light weight upper limb prosthesis. This… More >

Hongjian Wang^*, Jie Zheng^†, LiangWang^‡, Akiko Maehara^§, Chun Yang^II, David Muccigrosso^†, Richard Bachk^II, Jian Zhu^**, Gary S. Mintz^§, Dalin Tang^*,‡,††

Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 107-122, 2015, DOI:10.3970/mcb.2015.012.107

Abstract Computational modeling has been used extensively in cardiovascular and biological research, providing valuable information. However, 3D vulnerable plaque model construction with complex geometrical features and multicomponents is often very time consuming and not practical for clinical implementation. This paper investigated if 2D atherosclerotic plaque models could be used to replace 3D models to perform correlation analysis and achieve similar results. In vivo intravascular ultrasound (IVUS) coronary plaque data were acquired from a patient follow-up study to construct 2D structure-only and 3D FSI models to obtain plaque wall stress (PWS) and strain (PWSn) data. One hundred… More >

Francesca Cosmi^*

Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 87-105, 2015, DOI:10.3970/mcb.2015.012.087

Abstract Bone tissue is a complex multi-scale material and its morphological and functional characteristics are influenced during one’s life by constant changes, physiological and pathological. A recent technique can classify the mechanical response of trabecular bone by simulating the application of loads with a Cell Method model derived from plane radiographic images of the proximal epiphyses in the patient’s hand fingers, thus complementing the individual assessment with a low cost exam. The mesoscale pathological modifications (i.e. due to osteoporosis) can be detected and quantified, despite the simplification due to the use of radiograms. In this work, More >

Xi Zhao^∗, Youjun Liu^∗,†, Wenxin Wang^∗

Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 49-66, 2015, DOI:10.3970/mcb.2015.012.049

Abstract Purpose: Sequential graft and Y-type graft are two different surgical procedures in coronary artery bypass grafting (CABG). The hemodynamic environment of them are different, that may cause different short-term surgical result and long-term patency. In this study, the short-term and long-term result of sequential and Y-type graft was discussed by comparing the hemodynamics of them. Materials and Methods: Two postoperative 3-dimensional (3D) models were built by applying different graft on a patient-specific 3D model with serious stenosis. Then zero-dimensional (0D)/3D coupled simulation was carried out by coupling the postoperative 3D models with a 0D lumped… More >

P. Jhunjhunwala^∗,†, P.M. Padole^∗,‡, S.B. Thombre^∗,§

Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 37-47, 2015, DOI:10.3970/mcb.2015.012.037

Abstract CFD analysis plays an important role in the area of analysis of blood flow as in-vivo measurements of blood flow is costly and easily not accessible. This paper presents simulation of blood flow in healthy and stenosed coronary artery 2- D models. The simulation was done considering non-Newtonian behavior of blood and pulsatile nature of blood flow which is close to physical scenario. Pressure distribution, velocity distribution and wall shear were examined to understand their effect on Atherosclerosis. More >

Tong Li^∗, Prasad KDV Yarlagadda^∗, Adekunle Oloyede^∗, Namal Thibbotuwawa^∗, YuanTong Gu^∗,†

Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 17-35, 2015, DOI:10.3970/mcb.2015.012.017

Abstract Living cells are the functional unit of organs that controls reactions to their exterior. However, the mechanics of living cells can be difficult to characterize due to the crypticity of their microscale structures and associated dynamic cellular processes. Fortunately, multiscale modelling provides a powerful simulation tool that can be used to study the mechanical properties of these soft hierarchical, biological systems. This paper reviews recent developments in hierarchical multiscale modeling technique that aimed at understanding cytoskeleton mechanics. Discussions are expanded with respects to cytoskeletal components including: intermediate filaments, microtubules and microfilament networks. The mechanical performance More >

Chetan Kuthe^∗, R. V. Uddanwadiker^†, P. M. Padole^‡, A. A. Ramteke^§

Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 1-16, 2015, DOI:10.3970/mcb.2015.012.001

Abstract Skeletal muscles are responsible for the relative motion of the bones at the joints and provide the required strength. They exhibit highly nonlinear mechanical behaviour and are described by nonlinear hyperelastic constitutive relations. It is distinct from other biological soft tissue. Its hyperelastic or viscoelastic behaviour is modelled by using CE, SEE, and PEE. Contractile element simulates the behaviour of skeletal muscle when it is subjected to eccentric and concentric contraction. This research aims to estimate the stress induced in skeletal muscle in eccentric and concentric contraction with respect to the predefined strain. With the… More >

Jingjun Guo¹, Yanping Xiao²

CMES-Computer Modeling in Engineering & Sciences, Vol.109-110, No.6, pp. 519-536, 2015, DOI:10.3970/cmes.2015.109.519

Abstract We study the existence of collision local time of two independent subfractional Brownian motions with different coefficients in (-1/2,1/2) using an alternative expression. We prove that the collision local time is a Hida distribution based on the canonical framework of white noise analysis, and get chaos expansions. Finally, we show that the collision local time exists in (L2) under appropriate conditions. More >

E-N.G. Grylonakis¹, C.K. Filelis-Papadopoulos¹, G.A. Gravvanis¹

CMES-Computer Modeling in Engineering & Sciences, Vol.109-110, No.6, pp. 505-517, 2015, DOI:10.3970/cmes.2015.109.505

Abstract A new transform method for solving boundary value problems in two dimensions was proposed by A.S. Fokas, namely the unified transform. This approach seeks a solution to the unknown boundary values by solving a global relation, using the known boundary data. This relation can be used to characterize the Dirichlet to Neumann map. For the numerical solution of the global relation, a collocation-type method was recently introduced. Hence, the considered method is used for solving the 2D Laplace equation in several irregular convex polygons. The linear system, resulting from the collocation-type method, was solved by More >